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IDO1

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GENERAL INFORMATION

Gene name

 IDO1

Gene description

 Indoleamine 2,3-dioxygenase 1

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (EFO-21)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (EFO-21)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 IDO1 (HGNC Symbol)

Synonyms

 IDO, INDO

Description

 Indoleamine 2,3-dioxygenase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

Chromosome

 8

Cytoband

 p11.21

Chromosome location (bp)

 39902275 - 39928444

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131203 (version 83.38)

Entrez gene

 3620

UniProt

 P14902 (UniProt - Evidence at protein level)

neXtProt

 NX_P14902

Antibodypedia

 IDO1 antibodies

PROTEIN BROWSER
IDO1-001
IDO1-003
IDO1-004
IDO1-005
IDO1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IDO1-001
ENSP00000430950
ENST00000518237
P14902 [Direct mapping]
Indoleamine 2,3-dioxygenase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0002534 [cytokine production involved in inflammatory response]
GO:0002666 [positive regulation of T cell tolerance induction]
GO:0002678 [positive regulation of chronic inflammatory response]
GO:0002830 [positive regulation of type 2 immune response]
GO:0004833 [tryptophan 2,3-dioxygenase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006569 [tryptophan catabolic process]
GO:0006954 [inflammatory response]
GO:0007565 [female pregnancy]
GO:0009055 [electron carrier activity]
GO:0019441 [tryptophan catabolic process to kynurenine]
GO:0020037 [heme binding]
GO:0030485 [smooth muscle contractile fiber]
GO:0032421 [stereocilium bundle]
GO:0032496 [response to lipopolysaccharide]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0033555 [multicellular organismal response to stress]
GO:0033754 [indoleamine 2,3-dioxygenase activity]
GO:0034276 [kynurenic acid biosynthetic process]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036269 [swimming behavior]
GO:0042130 [negative regulation of T cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
GO:0070233 [negative regulation of T cell apoptotic process]
GO:0070234 [positive regulation of T cell apoptotic process]
Show all
 403 aa
45.3 kDa 		No 0
IDO1-003
ENSP00000429297
ENST00000518804
E5RIX2 [Direct mapping]
Indoleamine 2,3-dioxygenase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0020037 [heme binding]
Show all
 78 aa
9.2 kDa 		No 0
IDO1-004
ENSP00000429933
ENST00000522840
E5RH36 [Direct mapping]
Indoleamine 2,3-dioxygenase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0020037 [heme binding]
Show all
 47 aa
5.6 kDa 		No 0
IDO1-005
ENSP00000430505
ENST00000522495
P14902 [Direct mapping]
Indoleamine 2,3-dioxygenase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0004833 [tryptophan 2,3-dioxygenase activity]
GO:0005829 [cytosol]
GO:0006569 [tryptophan catabolic process]
GO:0007565 [female pregnancy]
GO:0009055 [electron carrier activity]
GO:0019441 [tryptophan catabolic process to kynurenine]
GO:0020037 [heme binding]
GO:0033754 [indoleamine 2,3-dioxygenase activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
GO:0070234 [positive regulation of T cell apoptotic process]
Show all
 403 aa
45.3 kDa 		No 0
IDO1-008
ENSP00000428716
ENST00000519154
E5RGR8 [Direct mapping]
Indoleamine 2,3-dioxygenase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0020037 [heme binding]
Show all
 180 aa
20.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.