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Gene name

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In atlas

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Method

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IDO1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

IDO1

Gene description

Indoleamine 2,3-dioxygenase 1

Protein class

Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (placenta)
GTEx:Tissue enhanced (lung)
FANTOM5:Tissue enhanced (placenta, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression

High cytoplasmic expression in lymphoid cells and placental endothelial cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 3 antibodies.
HPA023072 , HPA023149 , HPA027772
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
N/ACerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin020406080100120140TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin024681012RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta, thyroid gland)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina020406080Tags Per Million

GENE INFORMATION

Gene name

IDO1 (HGNC Symbol)

Synonyms

IDO, INDO

Description

Indoleamine 2,3-dioxygenase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

Chromosome

8

Cytoband

p11.21

Chromosome location (bp)

39902275 - 39928444

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131203 (version 83.38)

Entrez gene

3620

UniProt

P14902 (UniProt - Evidence at protein level)

neXtProt

NX_P14902

Antibodypedia

IDO1 antibodies

PROTEIN BROWSER

IDO1-001
IDO1-003
IDO1-004
IDO1-005
IDO1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IDO1-001
ENSP00000430950
ENST00000518237
P14902 [Direct mapping]
Indoleamine 2,3-dioxygenase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0002534 [cytokine production involved in inflammatory response]
GO:0002666 [positive regulation of T cell tolerance induction]
GO:0002678 [positive regulation of chronic inflammatory response]
GO:0002830 [positive regulation of type 2 immune response]
GO:0004833 [tryptophan 2,3-dioxygenase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006569 [tryptophan catabolic process]
GO:0006954 [inflammatory response]
GO:0007565 [female pregnancy]
GO:0009055 [electron carrier activity]
GO:0019441 [tryptophan catabolic process to kynurenine]
GO:0020037 [heme binding]
GO:0030485 [smooth muscle contractile fiber]
GO:0032421 [stereocilium bundle]
GO:0032496 [response to lipopolysaccharide]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0033555 [multicellular organismal response to stress]
GO:0033754 [indoleamine 2,3-dioxygenase activity]
GO:0034276 [kynurenic acid biosynthetic process]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0036269 [swimming behavior]
GO:0042130 [negative regulation of T cell proliferation]
GO:0043065 [positive regulation of apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
GO:0070233 [negative regulation of T cell apoptotic process]
GO:0070234 [positive regulation of T cell apoptotic process]
Show all
403 aa
45.3 kDa
No 0
IDO1-003
ENSP00000429297
ENST00000518804
E5RIX2 [Direct mapping]
Indoleamine 2,3-dioxygenase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0020037 [heme binding]
Show all
78 aa
9.2 kDa
No 0
IDO1-004
ENSP00000429933
ENST00000522840
E5RH36 [Direct mapping]
Indoleamine 2,3-dioxygenase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0020037 [heme binding]
Show all
47 aa
5.6 kDa
No 0
IDO1-005
ENSP00000430505
ENST00000522495
P14902 [Direct mapping]
Indoleamine 2,3-dioxygenase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0004833 [tryptophan 2,3-dioxygenase activity]
GO:0005829 [cytosol]
GO:0006569 [tryptophan catabolic process]
GO:0007565 [female pregnancy]
GO:0009055 [electron carrier activity]
GO:0019441 [tryptophan catabolic process to kynurenine]
GO:0020037 [heme binding]
GO:0033754 [indoleamine 2,3-dioxygenase activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
GO:0070234 [positive regulation of T cell apoptotic process]
Show all
403 aa
45.3 kDa
No 0
IDO1-008
ENSP00000428716
ENST00000519154
E5RGR8 [Direct mapping]
Indoleamine 2,3-dioxygenase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0020037 [heme binding]
Show all
180 aa
20.6 kDa
No 0

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