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HACL1

CANCER ATLAS

Gene description

 2-hydroxyacyl-CoA lyase 1

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035496
HPA035497

GENE INFORMATION

Gene name

 HACL1 (HGNC Symbol)

Synonyms

 2-HPCL, HPCL, PHYH2

Description

 2-hydroxyacyl-CoA lyase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 p25.1

Chromosome location (bp)

 15560704 - 15601852

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131373 (version 83.38)

Entrez gene

 26061

UniProt

 Q9UJ83 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJ83

Antibodypedia

 HACL1 antibodies

PROTEIN BROWSER
HACL1-001
HACL1-002
HACL1-003
HACL1-005
HACL1-007
HACL1-008
HACL1-009
HACL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HACL1-001
ENSP00000323811
ENST00000321169
Q9UJ83 [Direct mapping]
2-hydroxyacyl-CoA lyase 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001561 [fatty acid alpha-oxidation]
GO:0003824 [catalytic activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006629 [lipid metabolic process]
GO:0016829 [lyase activity]
GO:0016830 [carbon-carbon lyase activity]
GO:0030976 [thiamine pyrophosphate binding]
GO:0042802 [identical protein binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048037 [cofactor binding]
GO:0051259 [protein oligomerization]
Show all
 578 aa
63.7 kDa 		No 0
HACL1-002
ENSP00000403656
ENST00000451445
Q9UJ83 [Direct mapping]
2-hydroxyacyl-CoA lyase 1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001561 [fatty acid alpha-oxidation]
GO:0003824 [catalytic activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0016830 [carbon-carbon lyase activity]
GO:0030976 [thiamine pyrophosphate binding]
GO:0042802 [identical protein binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048037 [cofactor binding]
GO:0051259 [protein oligomerization]
Show all
 496 aa
54.7 kDa 		No 0
HACL1-003
ENSP00000395278
ENST00000435217
B3KPX4 [Direct mapping]
2-hydroxyacyl-CoA lyase 1; Phytanoyl-CoA 2-hydroxylase 2, isoform CRA_c; cDNA FLJ32415 fis, clone SKMUS2000724, highly similar to 2-hydroxyphytanoyl-CoA lyase (EC 4.1.-.-)
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
GO:0016829 [lyase activity]
GO:0030976 [thiamine pyrophosphate binding]
Show all
 337 aa
37.6 kDa 		No 0
HACL1-005
ENSP00000390699
ENST00000456194
Q9UJ83 [Direct mapping]
2-hydroxyacyl-CoA lyase 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001561 [fatty acid alpha-oxidation]
GO:0003824 [catalytic activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0016830 [carbon-carbon lyase activity]
GO:0030976 [thiamine pyrophosphate binding]
GO:0042802 [identical protein binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048037 [cofactor binding]
GO:0051259 [protein oligomerization]
Show all
 551 aa
61.1 kDa 		No 0
HACL1-007
ENSP00000404883
ENST00000457447
Q9UJ83 [Direct mapping]
2-hydroxyacyl-CoA lyase 1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001561 [fatty acid alpha-oxidation]
GO:0003824 [catalytic activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0016830 [carbon-carbon lyase activity]
GO:0030976 [thiamine pyrophosphate binding]
GO:0042802 [identical protein binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048037 [cofactor binding]
GO:0051259 [protein oligomerization]
Show all
 518 aa
56.7 kDa 		No 0
HACL1-008
ENSP00000391393
ENST00000421993
C9J306 [Direct mapping]
2-hydroxyacyl-CoA lyase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0030976 [thiamine pyrophosphate binding]
Show all
 244 aa
26.4 kDa 		No 0
HACL1-009
ENSP00000395352
ENST00000414979
C9JJM7 [Direct mapping]
2-hydroxyacyl-CoA lyase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0030976 [thiamine pyrophosphate binding]
Show all
 157 aa
17.1 kDa 		No 0
HACL1-201
ENSP00000486684
ENST00000628377
Q7Z773 [Direct mapping]
2-hydroxyacyl-CoA lyase 1; HACL1 protein
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0030976 [thiamine pyrophosphate binding]
Show all
 119 aa
12.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.