Expression of CHD1L in cancer - Summary

CANCER ATLAS

Gene description

Chromodomain helicase DNA binding protein 1-like

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA027789	HPA028670

GENE INFORMATION
Gene name	CHD1L (HGNC Symbol)
Synonyms	ALC1
Description	Chromodomain helicase DNA binding protein 1-like (HGNC Symbol)
Entrez gene summary	This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. [provided by RefSeq, Jan 2012]
Chromosome	1
Cytoband	q21.1
Chromosome location (bp)	147242641 - 147295766
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131778 (version 83.38)
Entrez gene	9557
UniProt	Q86WJ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q86WJ1
Antibodypedia	CHD1L antibodies

PROTEIN BROWSER

CHD1L-001	CHD1L-003	CHD1L-201	CHD1L-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHD1L-001 ENSP00000358262 ENST00000369258	Q86WJ1 [Direct mapping] Chromodomain-helicase-DNA-binding protein 1-like Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0004003 [ATP-dependent DNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006289 [nucleotide-excision repair] GO:0006338 [chromatin remodeling] GO:0006974 [cellular response to DNA damage stimulus] GO:0008026 [ATP-dependent helicase activity] GO:0016887 [ATPase activity] GO:0032508 [DNA duplex unwinding] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0070911 [global genome nucleotide-excision repair] Show all	897 aa 101 kDa	No	0
CHD1L-003 ENSP00000358263 ENST00000369259	Q86WJ1 [Direct mapping] Chromodomain-helicase-DNA-binding protein 1-like Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0004003 [ATP-dependent DNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006289 [nucleotide-excision repair] GO:0006338 [chromatin remodeling] GO:0006974 [cellular response to DNA damage stimulus] GO:0016887 [ATPase activity] GO:0032508 [DNA duplex unwinding] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0070911 [global genome nucleotide-excision repair] Show all	693 aa 77.8 kDa	No	0
CHD1L-201 ENSP00000355100 ENST00000361293	A0A0A0MRH8 [Direct mapping] Chromodomain-helicase-DNA-binding protein 1-like Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		616 aa 69.2 kDa	No	0
CHD1L-202 ENSP00000389031 ENST00000431239	A0A0A0MSH9 [Direct mapping] Chromodomain-helicase-DNA-binding protein 1-like Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0008026 [ATP-dependent helicase activity] GO:0008152 [metabolic process] Show all	797 aa 90 kDa	No	0