Cell atlas - CHD1L - The Human Protein Atlas

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CHD1L

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CHD1L
Gene description	Chromodomain helicase DNA binding protein 1-like
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA027789 , HPA028670
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA027789	A-431	Nucleoplasm
	HPA027789	U-2 OS	Nucleoplasm
	HPA027789	U-251 MG	Nucleoplasm
	HPA028670	A-431	Nucleoplasm
			Plasma membrane
			Cytosol
	HPA028670	U-2 OS	Nucleoplasm
	HPA028670	U-251 MG	Nucleoplasm
			Plasma membrane
			Cytosol

GENE INFORMATION
Gene name	CHD1L (HGNC Symbol)
Synonyms	ALC1
Description	Chromodomain helicase DNA binding protein 1-like (HGNC Symbol)
Entrez gene summary	This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. [provided by RefSeq, Jan 2012]
Chromosome	1
Cytoband	q21.1
Chromosome location (bp)	147242641 - 147295766
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131778 (version 83.38)
Entrez gene	9557
UniProt	Q86WJ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q86WJ1
Antibodypedia	CHD1L antibodies

PROTEIN BROWSER

CHD1L-001	CHD1L-003	CHD1L-201	CHD1L-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHD1L-001 ENSP00000358262 ENST00000369258	Q86WJ1 [Direct mapping] Chromodomain-helicase-DNA-binding protein 1-like Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0004003 [ATP-dependent DNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006289 [nucleotide-excision repair] GO:0006338 [chromatin remodeling] GO:0006974 [cellular response to DNA damage stimulus] GO:0008026 [ATP-dependent helicase activity] GO:0016887 [ATPase activity] GO:0032508 [DNA duplex unwinding] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0070911 [global genome nucleotide-excision repair] Show all	897 aa 101 kDa	No	0
CHD1L-003 ENSP00000358263 ENST00000369259	Q86WJ1 [Direct mapping] Chromodomain-helicase-DNA-binding protein 1-like Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0004003 [ATP-dependent DNA helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006281 [DNA repair] GO:0006289 [nucleotide-excision repair] GO:0006338 [chromatin remodeling] GO:0006974 [cellular response to DNA damage stimulus] GO:0016887 [ATPase activity] GO:0032508 [DNA duplex unwinding] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0070911 [global genome nucleotide-excision repair] Show all	693 aa 77.8 kDa	No	0
CHD1L-201 ENSP00000355100 ENST00000361293	A0A0A0MRH8 [Direct mapping] Chromodomain-helicase-DNA-binding protein 1-like Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		616 aa 69.2 kDa	No	0
CHD1L-202 ENSP00000389031 ENST00000431239	A0A0A0MSH9 [Direct mapping] Chromodomain-helicase-DNA-binding protein 1-like Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005524 [ATP binding] GO:0008026 [ATP-dependent helicase activity] GO:0008152 [metabolic process] Show all	797 aa 90 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.