Cell atlas - PTPRE - The Human Protein Atlas

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PTPRE

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Intermediate filaments

Human cell
	Intermediate Filaments

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GENERAL INFORMATION
Gene name	PTPRE
Gene description	Protein tyrosine phosphatase, receptor type, E
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the intermediate filaments.
RNA cell category	Cell line enhanced (TIME, HUVEC TERT2)
Protein evidence	Evidence at protein level
Main location	Localized to the Intermediate filaments (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA015870
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME, HUVEC TERT2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the intermediate filaments.

Main location

Intermediate filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA015870	A-431	No staining
	HPA015870	U-2 OS	Intermediate filaments
	HPA015870	U-251 MG	Intermediate filaments

GENE INFORMATION
Gene name	PTPRE (HGNC Symbol)
Synonyms	PTPE
Description	Protein tyrosine phosphatase, receptor type, E (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]
Chromosome	10
Cytoband	q26.2
Chromosome location (bp)	127907061 - 128085855
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132334 (version 83.38)
Entrez gene	5791
UniProt	P23469 (UniProt - Evidence at protein level)
neXtProt	NX_P23469
Antibodypedia	PTPRE antibodies

PROTEIN BROWSER

PTPRE-003	PTPRE-004	PTPRE-006	PTPRE-007	PTPRE-008	PTPRE-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTPRE-003 ENSP00000254667 ENST00000254667	P23469 [Direct mapping] Receptor-type tyrosine-protein phosphatase epsilon Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006470 [protein dephosphorylation] GO:0007185 [transmembrane receptor protein tyrosine phosphatase signaling pathway] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0033003 [regulation of mast cell activation] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0042803 [protein homodimerization activity] GO:0046627 [negative regulation of insulin receptor signaling pathway] Show all	700 aa 80.6 kDa	Yes	1
PTPRE-004 ENSP00000303350 ENST00000306042	P23469 [Direct mapping] Receptor-type tyrosine-protein phosphatase epsilon Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006470 [protein dephosphorylation] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0046627 [negative regulation of insulin receptor signaling pathway] Show all	642 aa 74.6 kDa	No	0
PTPRE-006 ENSP00000416939 ENST00000455661	Q5VWH5 [Direct mapping] Receptor-type tyrosine-protein phosphatase epsilon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	154 aa 17.2 kDa	Yes	1
PTPRE-007 ENSP00000410540 ENST00000442830	Q5VWH6 [Direct mapping] Receptor-type tyrosine-protein phosphatase epsilon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	140 aa 15.8 kDa	Yes	1
PTPRE-008 ENSP00000474102 ENST00000471218	S4R3B0 [Direct mapping] Receptor-type tyrosine-protein phosphatase epsilon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	149 aa 16.3 kDa	Yes	1
PTPRE-010 ENSP00000474830 ENST00000467366	S4R3X3 [Direct mapping] Receptor-type tyrosine-protein phosphatase epsilon Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		107 aa 11.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.