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Hepatocellular carcinomas showed strong cytoplasmic staining. Gliomas, several breast cancers along with a few cases of urothelial and endometrial cancers displayed moderate to strong positivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
PCED1A (HGNC Symbol)
Synonyms
bA12M19.1, C20orf81, FAM113A, FLJ22376
Description
PC-esterase domain containing 1A (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the GDSL/SGNH superfamily. Members of this family are hydrolytic enzymes with esterase and lipase activity and broad substrate specificity. This protein belongs to the Pmr5-Cas1p-esterase subfamily in that it contains the catalytic triad comprised of serine, aspartate and histidine and lacks two conserved regions (glycine after strand S2 and GxND motif). A pseudogene of this gene has been identified on the long arm of chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]
