Cell atlas - PCED1A - The Human Protein Atlas

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PCED1A

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PCED1A
Gene description	PC-esterase domain containing 1A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA050816
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA050816	A-431	Nucleoplasm
	HPA050816	A-431	Cytosol
	HPA050816	HeLa	Nucleoplasm
	HPA050816	HeLa	Cytosol
	HPA050816	U-2 OS	Nucleoplasm
	HPA050816	U-2 OS	Cytosol

GENE INFORMATION
Gene name	PCED1A (HGNC Symbol)
Synonyms	bA12M19.1, C20orf81, FAM113A, FLJ22376
Description	PC-esterase domain containing 1A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the GDSL/SGNH superfamily. Members of this family are hydrolytic enzymes with esterase and lipase activity and broad substrate specificity. This protein belongs to the Pmr5-Cas1p-esterase subfamily in that it contains the catalytic triad comprised of serine, aspartate and histidine and lacks two conserved regions (glycine after strand S2 and GxND motif). A pseudogene of this gene has been identified on the long arm of chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	2835314 - 2841190
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132635 (version 83.38)
Entrez gene	64773
UniProt	Q9H1Q7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H1Q7
Antibodypedia	PCED1A antibodies

PROTEIN BROWSER

PCED1A-001	PCED1A-002	PCED1A-003	PCED1A-004	PCED1A-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCED1A-001 ENSP00000349334 ENST00000356872	Q9H1Q7 [Direct mapping] PC-esterase domain-containing protein 1A Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	403 aa 46 kDa	No	0
PCED1A-002 ENSP00000388935 ENST00000448755	X6RC47 [Direct mapping] PC-esterase domain-containing protein 1A Show all	Predicted intracellular proteins Show all		229 aa 26.3 kDa	No	0
PCED1A-003 ENSP00000353868 ENST00000360652	Q9H1Q7 [Direct mapping] PC-esterase domain-containing protein 1A Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	454 aa 51.8 kDa	No	0
PCED1A-004 ENSP00000474824 ENST00000474714	S4R3X0 [Direct mapping] PC-esterase domain-containing protein 1A Show all	Predicted intracellular proteins Show all		127 aa 14.3 kDa	No	0
PCED1A-007 ENSP00000401711 ENST00000439542	X6RFT7 [Direct mapping] PC-esterase domain-containing protein 1A Show all	Predicted intracellular proteins Show all		280 aa 32.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.