Fields »
ABOUT
HELP
BLOG
PCNA

GENERAL INFORMATION

Gene name

 PCNA

Gene description

 Proliferating cell nuclear antigen

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear staining mainly in proliferative cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA030521 , HPA030522 , HPA030523 , CAB000148
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PCNA

Synonyms

Description

 Proliferating cell nuclear antigen (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p12.3

Chromosome location (bp)

 5114953 - 5126626

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132646 (version 83.38)

Entrez gene

 5111

UniProt

 P12004 (UniProt - Evidence at protein level)

neXtProt

 NX_P12004

Antibodypedia

 PCNA antibodies

PROTEIN BROWSER
PCNA-001
PCNA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PCNA-001
ENSP00000368438
ENST00000379143
P12004 [Direct mapping]
Proliferating cell nuclear antigen
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000701 [purine-specific mismatch base pair DNA N-glycosylase activity]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005663 [DNA replication factor C complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006272 [leading strand elongation]
GO:0006275 [regulation of DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006298 [mismatch repair]
GO:0008283 [cell proliferation]
GO:0019985 [translesion synthesis]
GO:0030337 [DNA polymerase processivity factor activity]
GO:0030855 [epithelial cell differentiation]
GO:0030971 [receptor tyrosine kinase binding]
GO:0032077 [positive regulation of deoxyribonuclease activity]
GO:0032139 [dinucleotide insertion or deletion binding]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0032405 [MutLalpha complex binding]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0042276 [error-prone translesion synthesis]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0042802 [identical protein binding]
GO:0043596 [nuclear replication fork]
GO:0043626 [PCNA complex]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0070062 [extracellular exosome]
GO:0070182 [DNA polymerase binding]
GO:0070557 [PCNA-p21 complex]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070987 [error-free translesion synthesis]
Show all
 261 aa
28.8 kDa 		No 0
PCNA-002
ENSP00000368458
ENST00000379160
P12004 [Direct mapping]
Proliferating cell nuclear antigen
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000701 [purine-specific mismatch base pair DNA N-glycosylase activity]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005663 [DNA replication factor C complex]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006272 [leading strand elongation]
GO:0006275 [regulation of DNA replication]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006298 [mismatch repair]
GO:0007507 [heart development]
GO:0008283 [cell proliferation]
GO:0019985 [translesion synthesis]
GO:0030331 [estrogen receptor binding]
GO:0030337 [DNA polymerase processivity factor activity]
GO:0030855 [epithelial cell differentiation]
GO:0030971 [receptor tyrosine kinase binding]
GO:0032077 [positive regulation of deoxyribonuclease activity]
GO:0032139 [dinucleotide insertion or deletion binding]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0032405 [MutLalpha complex binding]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0033993 [response to lipid]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0042276 [error-prone translesion synthesis]
GO:0042769 [DNA damage response, detection of DNA damage]
GO:0042802 [identical protein binding]
GO:0043596 [nuclear replication fork]
GO:0043626 [PCNA complex]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0046686 [response to cadmium ion]
GO:0070062 [extracellular exosome]
GO:0070182 [DNA polymerase binding]
GO:0070557 [PCNA-p21 complex]
GO:0070911 [global genome nucleotide-excision repair]
GO:0070987 [error-free translesion synthesis]
Show all
 261 aa
28.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.