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ARHGEF11

CANCER ATLAS

Gene description

 Rho guanine nucleotide exchange factor (GEF) 11

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA011026
HPA012037
HPA014658

GENE INFORMATION

Gene name

 ARHGEF11 (HGNC Symbol)

Synonyms

 GTRAP48, KIAA0380, PDZ-RHOGEF

Description

 Rho guanine nucleotide exchange factor (GEF) 11 (HGNC Symbol)

Entrez gene summary

 Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q23.1

Chromosome location (bp)

 156934840 - 157045370

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132694 (version 83.38)

Entrez gene

 9826

UniProt

 O15085 (UniProt - Evidence at protein level)

neXtProt

 NX_O15085

Antibodypedia

 ARHGEF11 antibodies

PROTEIN BROWSER
ARHGEF11-001
ARHGEF11-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF11-001
ENSP00000357177
ENST00000368194
O15085 [Direct mapping]
Rho guanine nucleotide exchange factor 11
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0001558 [regulation of cell growth]
GO:0001664 [G-protein coupled receptor binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006928 [movement of cell or subcellular component]
GO:0006941 [striated muscle contraction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0030010 [establishment of cell polarity]
GO:0030036 [actin cytoskeleton organization]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 1562 aa
172.2 kDa 		No 0
ARHGEF11-002
ENSP00000354644
ENST00000361409
O15085 [Direct mapping]
Rho guanine nucleotide exchange factor 11
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0001558 [regulation of cell growth]
GO:0001664 [G-protein coupled receptor binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006928 [movement of cell or subcellular component]
GO:0006941 [striated muscle contraction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0030010 [establishment of cell polarity]
GO:0030036 [actin cytoskeleton organization]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 1522 aa
167.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.