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ARHGEF11

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GENERAL INFORMATION

Gene name

 ARHGEF11

Gene description

 Rho guanine nucleotide exchange factor (GEF) 11

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane & the Golgi apparatus.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (approved), Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Approved based on 2 antibodies.
HPA012037 , HPA014658
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane & the Golgi apparatus.

Main location

 Golgi apparatus (approved), Plasma membrane (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA012037 A-431 No staining    
HPA012037 U-2 OS No staining    
HPA012037 U-251 MG Nucleoplasm
Plasma membrane
HPA014658 A-431 Golgi apparatus
Plasma membrane
HPA014658 U-2 OS No staining    
HPA014658 U-251 MG Golgi apparatus
Plasma membrane

GENE INFORMATION

Gene name

 ARHGEF11 (HGNC Symbol)

Synonyms

 GTRAP48, KIAA0380, PDZ-RHOGEF

Description

 Rho guanine nucleotide exchange factor (GEF) 11 (HGNC Symbol)

Entrez gene summary

 Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q23.1

Chromosome location (bp)

 156934840 - 157045370

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132694 (version 83.38)

Entrez gene

 9826

UniProt

 O15085 (UniProt - Evidence at protein level)

neXtProt

 NX_O15085

Antibodypedia

 ARHGEF11 antibodies

PROTEIN BROWSER
ARHGEF11-001
ARHGEF11-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF11-001
ENSP00000357177
ENST00000368194
O15085 [Direct mapping]
Rho guanine nucleotide exchange factor 11
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0001558 [regulation of cell growth]
GO:0001664 [G-protein coupled receptor binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006928 [movement of cell or subcellular component]
GO:0006941 [striated muscle contraction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0030010 [establishment of cell polarity]
GO:0030036 [actin cytoskeleton organization]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 1562 aa
172.2 kDa 		No 0
ARHGEF11-002
ENSP00000354644
ENST00000361409
O15085 [Direct mapping]
Rho guanine nucleotide exchange factor 11
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0001558 [regulation of cell growth]
GO:0001664 [G-protein coupled receptor binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006928 [movement of cell or subcellular component]
GO:0006941 [striated muscle contraction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0030010 [establishment of cell polarity]
GO:0030036 [actin cytoskeleton organization]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 1522 aa
167.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.