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MUTYH

CANCER ATLAS

Gene description

 MutY DNA glycosylase

Protein class

 Cancer-related genes, Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008732

GENE INFORMATION

Gene name

 MUTYH (HGNC Symbol)

Synonyms

 MYH

Description

 MutY DNA glycosylase (HGNC Symbol)

Entrez gene summary

 This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p34.1

Chromosome location (bp)

 45329163 - 45340470

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132781 (version 83.38)

Entrez gene

 4595

UniProt

 Q9UIF7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UIF7

Antibodypedia

 MUTYH antibodies

PROTEIN BROWSER
«
MUTYH-001
MUTYH-002
MUTYH-004
MUTYH-005
MUTYH-006
MUTYH-007
MUTYH-008
MUTYH-010
MUTYH-016
MUTYH-019
MUTYH-025
MUTYH-029
MUTYH-033
MUTYH-034
MUTYH-037
MUTYH-038
MUTYH-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MUTYH-001
ENSP00000361187
ENST00000372115
Q9UIF7 [Direct mapping]
A/G-specific adenine DNA glycosylase
E5KP27 [Target identity:100%; Query identity:100%]
A/G-specific adenine DNA glycosylase; MutY homolog (E. coli), isoform CRA_d
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006298 [mismatch repair]
GO:0016787 [hydrolase activity]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0032407 [MutSalpha complex binding]
GO:0045007 [depurination]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 535 aa
59.1 kDa 		No 0
MUTYH-002
ENSP00000361170
ENST00000372098
Q9UIF7 [Direct mapping]
A/G-specific adenine DNA glycosylase
E5KP26 [Target identity:100%; Query identity:100%]
A/G-specific adenine DNA glycosylase; MutY homolog (E. coli), isoform CRA_e
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006298 [mismatch repair]
GO:0006979 [response to oxidative stress]
GO:0016787 [hydrolase activity]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0019104 [DNA N-glycosylase activity]
GO:0032407 [MutSalpha complex binding]
GO:0045007 [depurination]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 546 aa
60.1 kDa 		No 0
MUTYH-004
ENSP00000361176
ENST00000372104
Q9UIF7 [Direct mapping]
A/G-specific adenine DNA glycosylase
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006298 [mismatch repair]
GO:0016787 [hydrolase activity]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0032407 [MutSalpha complex binding]
GO:0045007 [depurination]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 521 aa
57.4 kDa 		No 0
MUTYH-005
ENSP00000407590
ENST00000456914
Q9UIF7 [Direct mapping]
A/G-specific adenine DNA glycosylase
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006298 [mismatch repair]
GO:0016787 [hydrolase activity]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0032407 [MutSalpha complex binding]
GO:0045007 [depurination]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 521 aa
57.4 kDa 		No 0
MUTYH-006
ENSP00000409718
ENST00000448481
Q9UIF7 [Direct mapping]
A/G-specific adenine DNA glycosylase
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006298 [mismatch repair]
GO:0016787 [hydrolase activity]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0032407 [MutSalpha complex binding]
GO:0045007 [depurination]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 532 aa
58.4 kDa 		No 0
MUTYH-007
ENSP00000346354
ENST00000354383
Q9UIF7 [Direct mapping]
A/G-specific adenine DNA glycosylase
E5KP28 [Target identity:100%; Query identity:100%]
A/G-specific adenine DNA glycosylase; MutY homolog (E. coli), isoform CRA_b
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006298 [mismatch repair]
GO:0016787 [hydrolase activity]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0032407 [MutSalpha complex binding]
GO:0045007 [depurination]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 522 aa
57.5 kDa 		No 0
MUTYH-008
ENSP00000347685
ENST00000355498
Q9UIF7 [Direct mapping]
A/G-specific adenine DNA glycosylase
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006298 [mismatch repair]
GO:0016787 [hydrolase activity]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0032407 [MutSalpha complex binding]
GO:0045007 [depurination]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 521 aa
57.4 kDa 		No 0
MUTYH-010
ENSP00000361182
ENST00000372110
Q9UIF7 [Direct mapping]
A/G-specific adenine DNA glycosylase
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006298 [mismatch repair]
GO:0016787 [hydrolase activity]
GO:0016798 [hydrolase activity, acting on glycosyl bonds]
GO:0032407 [MutSalpha complex binding]
GO:0045007 [depurination]
GO:0046872 [metal ion binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 536 aa
59.1 kDa 		No 0
MUTYH-016
ENSP00000410263
ENST00000412971
Q5T418 [Direct mapping]
A/G-specific adenine DNA glycosylase
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 215 aa
23.2 kDa 		No 0
MUTYH-019
ENSP00000403655
ENST00000435155
Q5T413 [Direct mapping]
A/G-specific adenine DNA glycosylase
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 291 aa
31.9 kDa 		No 0
MUTYH-025
ENSP00000436469
ENST00000483127
E9PP34 [Direct mapping]
A/G-specific adenine DNA glycosylase
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 94 aa
10.7 kDa 		No 0
MUTYH-029
ENSP00000432330
ENST00000488731
E9PNY0 [Direct mapping]
A/G-specific adenine DNA glycosylase
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 216 aa
23.6 kDa 		No 0
MUTYH-033
ENSP00000433130
ENST00000528013
E9PM53 [Direct mapping]
A/G-specific adenine DNA glycosylase
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0016787 [hydrolase activity]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 535 aa
58.7 kDa 		No 0
MUTYH-034
ENSP00000437093
ENST00000529984
E9PNY0 [Direct mapping]
A/G-specific adenine DNA glycosylase
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
Show all
 216 aa
23.6 kDa 		No 0
MUTYH-037
ENSP00000431292
ENST00000531105
E9PLT4 [Direct mapping]
A/G-specific adenine DNA glycosylase
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 62 aa
6.4 kDa 		No 0
MUTYH-038
ENSP00000432528
ENST00000529892
H0YCY5 [Direct mapping]
A/G-specific adenine DNA glycosylase
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0006281 [DNA repair]
GO:0016787 [hydrolase activity]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 213 aa
23.4 kDa 		No 0
MUTYH-201
ENSP00000408176
ENST00000450313
E5KP25 [Direct mapping]
A/G-specific adenine DNA glycosylase
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005634 [nucleus]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0016787 [hydrolase activity]
GO:0051539 [4 iron, 4 sulfur cluster binding]
Show all
 549 aa
60.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.