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Malignant gliomas as well as several cases of malignant carcinoids, hepatocellular carcinomas, malignant melanomas and pancreatic cancer exhibited moderate to strong cytoplasmic positivity. Other malignancies were in general negative.
GENE INFORMATION
Gene name
ANGPTL3 (HGNC Symbol)
Synonyms
ANGPT5
Description
Angiopoietin-like 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015]