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ANGPTL3

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GENERAL INFORMATION

Gene name

 ANGPTL3

Gene description

 Angiopoietin-like 3

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ANGPTL3 (HGNC Symbol)

Synonyms

 ANGPT5

Description

 Angiopoietin-like 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015]

Chromosome

 1

Cytoband

 p31.3

Chromosome location (bp)

 62597487 - 62606159

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132855 (version 83.38)

Entrez gene

 27329

UniProt

 Q9Y5C1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5C1

Antibodypedia

 ANGPTL3 antibodies

PROTEIN BROWSER
ANGPTL3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANGPTL3-001
ENSP00000360170
ENST00000371129
Q9Y5C1 [Direct mapping]
Angiopoietin-related protein 3
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004857 [enzyme inhibitor activity]
GO:0004859 [phospholipase inhibitor activity]
GO:0005178 [integrin binding]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0006071 [glycerol metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0007160 [cell-matrix adhesion]
GO:0007165 [signal transduction]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008083 [growth factor activity]
GO:0008203 [cholesterol metabolic process]
GO:0009395 [phospholipid catabolic process]
GO:0009725 [response to hormone]
GO:0009986 [cell surface]
GO:0010519 [negative regulation of phospholipase activity]
GO:0019915 [lipid storage]
GO:0030335 [positive regulation of cell migration]
GO:0042632 [cholesterol homeostasis]
GO:0045766 [positive regulation of angiogenesis]
GO:0048844 [artery morphogenesis]
GO:0050996 [positive regulation of lipid catabolic process]
GO:0051005 [negative regulation of lipoprotein lipase activity]
GO:0055088 [lipid homeostasis]
GO:0055090 [acylglycerol homeostasis]
GO:0055091 [phospholipid homeostasis]
GO:0070328 [triglyceride homeostasis]
Show all
 460 aa
53.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.