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SYT4

GENERAL INFORMATION

Gene name

 SYT4

Gene description

 Synaptotagmin IV

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, adrenal gland)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Group enriched (cerebellum, pituitary gland, brain, caudate, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in CNS and adrenal gland.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA010574
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, pituitary gland, brain, caudate, hippocampus)

GENE INFORMATION

Gene name

 SYT4 (HGNC Symbol)

Synonyms

 HsT1192, KIAA1342

Description

 Synaptotagmin IV (HGNC Symbol)

Entrez gene summary

Chromosome

 18

Cytoband

 q12.3

Chromosome location (bp)

 43267878 - 43277650

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000132872 (version 83.38)

Entrez gene

 6860

UniProt

 Q9H2B2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H2B2

Antibodypedia

 SYT4 antibodies

PROTEIN BROWSER
SYT4-001
SYT4-004
SYT4-012
SYT4-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYT4-001
ENSP00000255224
ENST00000255224
Q9H2B2 [Direct mapping]
Synaptotagmin-4
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0001786 [phosphatidylserine binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007269 [neurotransmitter secretion]
GO:0007420 [brain development]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030054 [cell junction]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0031045 [dense core granule]
GO:0031339 [negative regulation of vesicle fusion]
GO:0043005 [neuron projection]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045955 [negative regulation of calcium ion-dependent exocytosis]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:1903861 [positive regulation of dendrite extension]
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 425 aa
48 kDa 		No 0
SYT4-004
ENSP00000466930
ENST00000590752
Q9H2B2 [Direct mapping]
Synaptotagmin-4
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Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030054 [cell junction]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:1903861 [positive regulation of dendrite extension]
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 407 aa
46.1 kDa 		No 0
SYT4-012
ENSP00000470516
ENST00000596867
M0QZF3 [Direct mapping]
Synaptotagmin-4
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Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005623 [cell]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
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 103 aa
11.7 kDa 		No 0
SYT4-013
ENSP00000472583
ENST00000593720
M0R2I0 [Direct mapping]
Synaptotagmin-4
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005623 [cell]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 144 aa
16.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.