Cell atlas - TPTE2 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TPTE2
Gene description	Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
Protein class	Enzymes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Group enriched (HDLM-2, Karpas-707)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Endoplasmic reticulum (supported)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA068342
	SHOW MORE

ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HDLM-2, Karpas-707) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the endoplasmic reticulum. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Cytosol (approved)

Additional location

Endoplasmic reticulum (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA068342	MCF7	No staining
HPA068342	PC-3	Cytosol
HPA068342	U-2 OS	Endoplasmic reticulum
HPA068342	U-2 OS	Cytosol

GENE INFORMATION
Gene name	TPTE2 (HGNC Symbol)
Synonyms	TPIP
Description	Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 (HGNC Symbol)
Entrez gene summary	TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002]
Chromosome	13
Cytoband	q12.11
Chromosome location (bp)	19422877 - 19536762
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132958 (version 83.38)
Entrez gene	93492
UniProt	Q6XPS3 (UniProt - Evidence at protein level)
neXtProt	NX_Q6XPS3
Antibodypedia	TPTE2 antibodies

PROTEIN BROWSER

TPTE2-001	TPTE2-003	TPTE2-201	TPTE2-202	TPTE2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPTE2-001 ENSP00000372438 ENST00000382978	Q6XPS3 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Show all	GO:0000139 [Golgi membrane] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006470 [protein dephosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016314 [phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0044281 [small molecule metabolic process] Show all	482 aa 56.3 kDa	No	3
TPTE2-003 ENSP00000375098 ENST00000390680	Q6XPS3 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Show all	GO:0000139 [Golgi membrane] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006470 [protein dephosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016314 [phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0044281 [small molecule metabolic process] Show all	445 aa 52.2 kDa	No	3
TPTE2-201 ENSP00000255310 ENST00000255310	Q6XPS3 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Show all	GO:0000139 [Golgi membrane] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006470 [protein dephosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016314 [phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0044281 [small molecule metabolic process] Show all	445 aa 52.2 kDa	No	3
TPTE2-202 ENSP00000382974 ENST00000400103	Q6XPS3 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Show all	GO:0000139 [Golgi membrane] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006470 [protein dephosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016314 [phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0044281 [small molecule metabolic process] Show all	411 aa 48.4 kDa	No	1
TPTE2-203 ENSP00000383089 ENST00000400230	Q6XPS3 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Show all	GO:0000139 [Golgi membrane] GO:0004725 [protein tyrosine phosphatase activity] GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006470 [protein dephosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0006811 [ion transport] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016314 [phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	522 aa 61.1 kDa	No	4