Tissue expression of TPTE2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TPTE2
Gene description	Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
Protein class	Enzymes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (testis)
GTEx:	Tissue enriched (testis)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)

GENE INFORMATION
Gene name	TPTE2 (HGNC Symbol)
Synonyms	TPIP
Description	Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 (HGNC Symbol)
Entrez gene summary	TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002]
Chromosome	13
Cytoband	q12.11
Chromosome location (bp)	19422877 - 19536762
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132958 (version 83.38)
Entrez gene	93492
UniProt	Q6XPS3 (UniProt - Evidence at protein level)
neXtProt	NX_Q6XPS3
Antibodypedia	TPTE2 antibodies

PROTEIN BROWSER

TPTE2-001	TPTE2-003	TPTE2-201	TPTE2-202	TPTE2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPTE2-001 ENSP00000372438 ENST00000382978	Q6XPS3 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Show all	GO:0000139 [Golgi membrane] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006470 [protein dephosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016314 [phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0044281 [small molecule metabolic process] Show all	482 aa 56.3 kDa	No	3
TPTE2-003 ENSP00000375098 ENST00000390680	Q6XPS3 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Show all	GO:0000139 [Golgi membrane] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006470 [protein dephosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016314 [phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0044281 [small molecule metabolic process] Show all	445 aa 52.2 kDa	No	3
TPTE2-201 ENSP00000255310 ENST00000255310	Q6XPS3 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Show all	GO:0000139 [Golgi membrane] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006470 [protein dephosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016314 [phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0044281 [small molecule metabolic process] Show all	445 aa 52.2 kDa	No	3
TPTE2-202 ENSP00000382974 ENST00000400103	Q6XPS3 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Show all	GO:0000139 [Golgi membrane] GO:0004725 [protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006470 [protein dephosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016314 [phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0044281 [small molecule metabolic process] Show all	411 aa 48.4 kDa	No	1
TPTE2-203 ENSP00000383089 ENST00000400230	Q6XPS3 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Show all	GO:0000139 [Golgi membrane] GO:0004725 [protein tyrosine phosphatase activity] GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006470 [protein dephosphorylation] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0006811 [ion transport] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016314 [phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	522 aa 61.1 kDa	No	4