Cell atlas - PRAM1 - The Human Protein Atlas

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PRAM1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	PRAM1
Gene description	PML-RARA regulated adaptor molecule 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (U-937, THP-1, HL-60)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA045236
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-937, THP-1, HL-60) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA045236	NB-4	Golgi apparatus
	HPA045236	U-2 OS	No staining

GENE INFORMATION
Gene name	PRAM1 (HGNC Symbol)
Synonyms	PML-RAR
Description	PML-RARA regulated adaptor molecule 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	8490056 - 8503112
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133246 (version 83.38)
Entrez gene	84106
UniProt	Q96QH2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96QH2
Antibodypedia	PRAM1 antibodies

PROTEIN BROWSER

PRAM1-001	PRAM1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRAM1-001 ENSP00000408342 ENST00000423345	Q96QH2 [Direct mapping] PML-RARA-regulated adapter molecule 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007229 [integrin-mediated signaling pathway] GO:0008289 [lipid binding] GO:0043313 [regulation of neutrophil degranulation] Show all	670 aa 74 kDa	No	0
PRAM1-004 ENSP00000471634 ENST00000600262	M0R149 [Direct mapping] PML-RARA-regulated adapter molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		180 aa 19.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.