Tissue expression of PRAM1 - Summary - The Human Protein Atlas

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PRAM1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PRAM1
Gene description	PML-RARA regulated adaptor molecule 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (bone marrow)
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in subsets of immune cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA050161
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (bone marrow)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)

GENE INFORMATION
Gene name	PRAM1 (HGNC Symbol)
Synonyms	PML-RAR
Description	PML-RARA regulated adaptor molecule 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	8490056 - 8503112
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000133246 (version 83.38)
Entrez gene	84106
UniProt	Q96QH2 (UniProt - Evidence at protein level)
neXtProt	NX_Q96QH2
Antibodypedia	PRAM1 antibodies

PROTEIN BROWSER

PRAM1-001	PRAM1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRAM1-001 ENSP00000408342 ENST00000423345	Q96QH2 [Direct mapping] PML-RARA-regulated adapter molecule 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007229 [integrin-mediated signaling pathway] GO:0008289 [lipid binding] GO:0043313 [regulation of neutrophil degranulation] Show all	670 aa 74 kDa	No	0
PRAM1-004 ENSP00000471634 ENST00000600262	M0R149 [Direct mapping] PML-RARA-regulated adapter molecule 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		180 aa 19.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.