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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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SFTPD
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SFTPD

Gene description

Surfactant protein D

Protein class

Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (lung)
GTEx:Tissue enriched (lung)
FANTOM5:Tissue enriched (lung)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in pneumocytes.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA044582 , HPA056768 , CAB004578
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (lung)

GENE INFORMATION

Gene name

SFTPD (HGNC Symbol)

Synonyms

COLEC7, SFTP4, SP-D

Description

Surfactant protein D (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]

Chromosome

10

Cytoband

q22.3

Chromosome location (bp)

79937740 - 79982614

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000133661 (version 83.38)

Entrez gene

6441

UniProt

P35247 (UniProt - Evidence at protein level)

neXtProt

NX_P35247

Antibodypedia

SFTPD antibodies

PROTEIN BROWSER

SFTPD-001
SFTPD-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SFTPD-001
ENSP00000361366
ENST00000372292
P35247 [Direct mapping]
Pulmonary surfactant-associated protein D
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817 [regulation of cytokine production]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006898 [receptor-mediated endocytosis]
GO:0007585 [respiratory gaseous exchange]
GO:0030139 [endocytic vesicle]
GO:0030246 [carbohydrate binding]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042742 [defense response to bacterium]
GO:0043129 [surfactant homeostasis]
GO:0044267 [cellular protein metabolic process]
GO:0045085 [negative regulation of interleukin-2 biosynthetic process]
GO:0045087 [innate immune response]
GO:0045334 [clathrin-coated endocytic vesicle]
GO:0048246 [macrophage chemotaxis]
GO:0048286 [lung alveolus development]
GO:0050766 [positive regulation of phagocytosis]
GO:0050776 [regulation of immune response]
GO:0072593 [reactive oxygen species metabolic process]
Show all
375 aa
37.7 kDa
Yes 0
SFTPD-002
ENSP00000394325
ENST00000444384
Q5T0M2 [Direct mapping]
Pulmonary surfactant-associated protein D
Show all
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
218 aa
21 kDa
Yes 0

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