Expression of LOXL2 in cancer - Summary

CANCER ATLAS

Gene description

Lysyl oxidase-like 2

Protein class

Enzymes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB025848

GENE INFORMATION
Gene name	LOXL2 (HGNC Symbol)
Synonyms	WS9-14
Description	Lysyl oxidase-like 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	23297189 - 23425328
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134013 (version 83.38)
Entrez gene	4017
UniProt	Q9Y4K0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y4K0
Antibodypedia	LOXL2 antibodies

PROTEIN BROWSER

LOXL2-001	LOXL2-005	LOXL2-009	LOXL2-010	LOXL2-012	LOXL2-013	LOXL2-014	LOXL2-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LOXL2-001 ENSP00000373783 ENST00000389131	Q9Y4K0 [Direct mapping] Lysyl oxidase homolog 2 Show all	Enzymes ENZYME proteins Oxidoreductases THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0001837 [epithelial to mesenchymal transition] GO:0001935 [endothelial cell proliferation] GO:0002040 [sprouting angiogenesis] GO:0003682 [chromatin binding] GO:0003714 [transcription corepressor activity] GO:0004720 [protein-lysine 6-oxidase activity] GO:0005044 [scavenger receptor activity] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006351 [transcription, DNA-templated] GO:0006464 [cellular protein modification process] GO:0006898 [receptor-mediated endocytosis] GO:0007155 [cell adhesion] GO:0007568 [aging] GO:0009055 [electron carrier activity] GO:0016020 [membrane] GO:0016570 [histone modification] GO:0016641 [oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor] GO:0018277 [protein deamination] GO:0030199 [collagen fibril organization] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0035064 [methylated histone binding] GO:0043542 [endothelial cell migration] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046688 [response to copper ion] GO:0055114 [oxidation-reduction process] GO:0070492 [oligosaccharide binding] Show all	774 aa 86.7 kDa	Yes	0
LOXL2-005 ENSP00000427907 ENST00000520349	H0YAR1 [Direct mapping] Lysyl oxidase homolog 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	207 aa 22.3 kDa	No	0
LOXL2-009 ENSP00000429778 ENST00000520871	E5RHH3 [Direct mapping] Lysyl oxidase homolog 2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	218 aa 23.8 kDa	No	0
LOXL2-010 ENSP00000428933 ENST00000519243	E5RFE2 [Direct mapping] Lysyl oxidase homolog 2 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	96 aa 10.9 kDa	Yes	0
LOXL2-012 ENSP00000428497 ENST00000524168	E5RI22 [Direct mapping] Lysyl oxidase homolog 2 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	139 aa 15.5 kDa	Yes	0
LOXL2-013 ENSP00000430519 ENST00000518083	E5RJL2 [Direct mapping] Lysyl oxidase homolog 2 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	151 aa 16.8 kDa	Yes	0
LOXL2-014 ENSP00000427883 ENST00000524144	E5RFY0 [Direct mapping] Lysyl oxidase homolog 2 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	258 aa 27.8 kDa	No	0
LOXL2-016 ENSP00000473322 ENST00000523833	R4GMS2 [Direct mapping] Lysyl oxidase homolog 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		101 aa 11.2 kDa	Yes	0