Cell atlas - CAMK1 - The Human Protein Atlas

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CAMK1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	CAMK1
Gene description	Calcium/calmodulin-dependent protein kinase I
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Mouse	Localized to the Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA051409
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051409	HEK 293	Cytosol
	HPA051409	HeLa	No staining
	HPA051409	U-2 OS	No staining

MOUSE CELLS

Main location

Cytosol

Mouse gene

ENSMUSG00000030272 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA051409	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	CAMK1 (HGNC Symbol)
Synonyms	CaMKI
Description	Calcium/calmodulin-dependent protein kinase I (HGNC Symbol)
Entrez gene summary	Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p25.3
Chromosome location (bp)	9757342 - 9769992
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134072 (version 83.38)
Entrez gene	8536
UniProt	Q14012 (UniProt - Evidence at protein level)
neXtProt	NX_Q14012
Antibodypedia	CAMK1 antibodies

PROTEIN BROWSER

CAMK1-001	CAMK1-005	CAMK1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAMK1-001 ENSP00000256460 ENST00000256460	Q14012 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1 B0YIY3 [Target identity:100%; Query identity:100%] Calcium/calmodulin-dependent protein kinase I, isoform CRA_a; Calcium/calmodulin-dependent protein kinase type 1; cDNA, FLJ95825, Homo sapiens calcium/calmodulin-dependent protein kinase I (CAMK1),mRNA Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006913 [nucleocytoplasmic transport] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0010976 [positive regulation of neuron projection development] GO:0032091 [negative regulation of protein binding] GO:0032880 [regulation of protein localization] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0043393 [regulation of protein binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046827 [positive regulation of protein export from nucleus] GO:0051147 [regulation of muscle cell differentiation] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051835 [positive regulation of synapse structural plasticity] GO:0060143 [positive regulation of syncytium formation by plasma membrane fusion] GO:0060999 [positive regulation of dendritic spine development] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:1901985 [positive regulation of protein acetylation] Show all	370 aa 41.3 kDa	No	1
CAMK1-005 ENSP00000393238 ENST00000421120	H7C071 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	260 aa 28.5 kDa	No	1
CAMK1-006 ENSP00000404587 ENST00000411972	C9JES6 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	122 aa 14 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.