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MEIS2

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GENERAL INFORMATION

Gene name

 MEIS2

Gene description

 Meis homeobox 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Cell line enhanced (SH-SY5Y)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

Additional location

 In addition localized to the Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA003256
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (approved)

Additional location

 Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA003256 A-431 Nucleoplasm
Cytosol
HPA003256 U-2 OS Nucleoplasm
Cytosol
HPA003256 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 MEIS2 (HGNC Symbol)

Synonyms

 HsT18361, MRG1

Description

 Meis homeobox 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q14

Chromosome location (bp)

 36889204 - 37101299

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134138 (version 83.38)

Entrez gene

 4212

UniProt

 O14770 (UniProt - Evidence at protein level)

neXtProt

 NX_O14770

Antibodypedia

 MEIS2 antibodies

PROTEIN BROWSER
«
MEIS2-001
MEIS2-002
MEIS2-003
MEIS2-005
MEIS2-007
MEIS2-008
MEIS2-015
MEIS2-017
MEIS2-018
MEIS2-021
MEIS2-028
MEIS2-030
MEIS2-031
MEIS2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MEIS2-001
ENSP00000453793
ENST00000561208
O14770 [Direct mapping]
Homeobox protein Meis2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001654 [eye development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0008542 [visual learning]
GO:0009612 [response to mechanical stimulus]
GO:0031016 [pancreas development]
GO:0043565 [sequence-specific DNA binding]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070848 [response to growth factor]
Show all
 477 aa
51.8 kDa 		No 0
MEIS2-002
ENSP00000341400
ENST00000338564
O14770 [Direct mapping]
Homeobox protein Meis2
A0A024R9L4 [Target identity:100%; Query identity:100%]
Meis1, myeloid ecotropic viral integration site 1 homolog 2 (Mouse), isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 470 aa
51.1 kDa 		No 0
MEIS2-003
ENSP00000404185
ENST00000424352
O14770 [Direct mapping]
Homeobox protein Meis2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 401 aa
43.8 kDa 		No 0
MEIS2-005
ENSP00000380745
ENST00000397620
O14770 [Direct mapping]
Homeobox protein Meis2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 306 aa
33.6 kDa 		No 0
MEIS2-007
ENSP00000380749
ENST00000397624
O14770 [Direct mapping]
Homeobox protein Meis2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 306 aa
33.6 kDa 		No 0
MEIS2-008
ENSP00000453390
ENST00000559085
O14770 [Direct mapping]
Homeobox protein Meis2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 388 aa
42.3 kDa 		No 0
MEIS2-015
ENSP00000452874
ENST00000560617
H0YKN2 [Direct mapping]
Homeobox protein Meis2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 105 aa
11.5 kDa 		No 0
MEIS2-017
ENSP00000452693
ENST00000557796
O14770 [Direct mapping]
Homeobox protein Meis2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 381 aa
41.5 kDa 		No 0
MEIS2-018
ENSP00000453782
ENST00000558313
H0YMX5 [Direct mapping]
Homeobox protein Meis2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 157 aa
17 kDa 		No 0
MEIS2-021
ENSP00000452770
ENST00000560697
H0YKE5 [Direct mapping]
Homeobox protein Meis2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 94 aa
10.4 kDa 		No 0
MEIS2-028
ENSP00000453497
ENST00000559561
O14770 [Direct mapping]
Homeobox protein Meis2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 394 aa
43.1 kDa 		No 0
MEIS2-030
ENSP00000475899
ENST00000607277
U3KQI2 [Direct mapping]
Homeobox protein Meis2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 235 aa
26 kDa 		No 0
MEIS2-031
ENSP00000475660
ENST00000606653
U3KQ95 [Direct mapping]
Homeobox protein Meis2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 139 aa
15.6 kDa 		No 0
MEIS2-201
ENSP00000339549
ENST00000340545
O14770 [Direct mapping]
Homeobox protein Meis2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008134 [transcription factor binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 381 aa
41.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.