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Gene name

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NOTCH2
  • TISSUE

  • premium

    CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

NOTCH2

Gene description

Notch 2

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

Uncertain based on 2 antibodies.
HPA046392 , HPA048743
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
N/A
Cerebral cortex
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Thyroid gland
N/A
Parathyroid gland
N/A
Adrenal gland
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Bone marrow
N/A
Lymph node
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Heart muscle
N/A
Skeletal muscle
N/A
Smooth muscle
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Gallbladder
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Salivary gland
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Small intestine
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
Prostate
N/A
Seminal vesicle
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
Endometrium
N/A
Fallopian tube
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Adipose tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin01020304050TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin05101520RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina024681012Tags Per Million

GENE INFORMATION

Gene name

NOTCH2

Synonyms

Description

Notch 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Chromosome

1

Cytoband

p12

Chromosome location (bp)

119911553 - 120069626

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134250 (version 83.38)

Entrez gene

4853

UniProt

Q04721 (UniProt - Evidence at protein level)

neXtProt

NX_Q04721

Antibodypedia

NOTCH2 antibodies

PROTEIN BROWSER

NOTCH2-001
NOTCH2-006
NOTCH2-201
NOTCH2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NOTCH2-001
ENSP00000256646
ENST00000256646
Q04721 [Direct mapping]
Neurogenic locus notch homolog protein 2 Notch 2 extracellular truncation Notch 2 intracellular domain
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000139 [Golgi membrane]
GO:0001701 [in utero embryonic development]
GO:0001709 [cell fate determination]
GO:0001889 [liver development]
GO:0001890 [placenta development]
GO:0002011 [morphogenesis of an epithelial sheet]
GO:0002315 [marginal zone B cell differentiation]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0003184 [pulmonary valve morphogenesis]
GO:0004872 [receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005929 [cilium]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006959 [humoral immune response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007220 [Notch receptor processing]
GO:0007275 [multicellular organismal development]
GO:0007368 [determination of left/right symmetry]
GO:0007399 [nervous system development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009887 [organ morphogenesis]
GO:0009986 [cell surface]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016049 [cell growth]
GO:0019827 [stem cell population maintenance]
GO:0030097 [hemopoiesis]
GO:0030154 [cell differentiation]
GO:0030326 [embryonic limb morphogenesis]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0035264 [multicellular organism growth]
GO:0035622 [intrahepatic bile duct development]
GO:0038049 [transcription factor activity, ligand-activated RNA polymerase II transcription factor binding]
GO:0042246 [tissue regeneration]
GO:0042742 [defense response to bacterium]
GO:0043011 [myeloid dendritic cell differentiation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046849 [bone remodeling]
GO:0050793 [regulation of developmental process]
GO:0060413 [atrial septum morphogenesis]
GO:0060674 [placenta blood vessel development]
GO:0061073 [ciliary body morphogenesis]
GO:0061314 [Notch signaling involved in heart development]
GO:0072574 [hepatocyte proliferation]
GO:0072576 [liver morphogenesis]
GO:0072602 [interleukin-4 secretion]
GO:1990705 [cholangiocyte proliferation]
Show all
2471 aa
265.4 kDa
Yes 1
NOTCH2-006
ENSP00000473427
ENST00000602566
R4GN02 [Direct mapping]
Neurogenic locus notch homolog protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
235 aa
25.5 kDa
No 0
NOTCH2-201
ENSP00000477065
ENST00000579475
D2WEZ3 [Direct mapping]
Neurogenic locus notch homolog protein 2; Neurogenic locus notch-like protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
863 aa
92.6 kDa
No 0
NOTCH2-202
ENSP00000479088
ENST00000612822
A0A087WV16 [Direct mapping]
Neurogenic locus notch homolog protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
Show all
236 aa
25.8 kDa
No 0

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The Human Protein Atlas project is funded
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