Expression of AP4B1 in cancer - Summary

CANCER ATLAS

Gene description

Adaptor-related protein complex 4, beta 1 subunit

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA028652

GENE INFORMATION
Gene name	AP4B1 (HGNC Symbol)
Synonyms	BETA-4, SPG47
Description	Adaptor-related protein complex 4, beta 1 subunit (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans-Golgi network to the endosomal-lysosomal system. Mutations in this gene are associated with cerebral palsy spastic quadriplegic type 5 (CPSQ5) disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	1
Cytoband	p13.2
Chromosome location (bp)	113894748 - 113905201
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134262 (version 83.38)
Entrez gene	10717
UniProt	Q9Y6B7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6B7
Antibodypedia	AP4B1 antibodies

PROTEIN BROWSER

AP4B1-001	AP4B1-002	AP4B1-005	AP4B1-007	AP4B1-008	AP4B1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AP4B1-001 ENSP00000256658 ENST00000256658	Q9Y6B7 [Direct mapping] AP-4 complex subunit beta-1 A0A024R0D2 [Target identity:100%; Query identity:100%] AP complex subunit beta Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0005905 [coated pit] GO:0006886 [intracellular protein transport] GO:0006892 [post-Golgi vesicle-mediated transport] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0016192 [vesicle-mediated transport] GO:0030117 [membrane coat] GO:0030131 [clathrin adaptor complex] GO:0031904 [endosome lumen] GO:0032588 [trans-Golgi network membrane] GO:0061024 [membrane organization] Show all	739 aa 83.3 kDa	No	0
AP4B1-002 ENSP00000358580 ENST00000369567	B1ALD0 [Direct mapping] AP complex subunit beta Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0006886 [intracellular protein transport] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0016192 [vesicle-mediated transport] GO:0030117 [membrane coat] GO:0030131 [clathrin adaptor complex] Show all	571 aa 64.6 kDa	No	0
AP4B1-005 ENSP00000358577 ENST00000369564	B1ALD1 [Direct mapping] AP-4 complex subunit beta-1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030117 [membrane coat] Show all	296 aa 33.6 kDa	No	0
AP4B1-007 ENSP00000358584 ENST00000369571	B1ALD2 [Direct mapping] AP-4 complex subunit beta-1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030117 [membrane coat] Show all	262 aa 29.6 kDa	No	0
AP4B1-008 ENSP00000393622 ENST00000432415	B1ALD3 [Direct mapping] AP-4 complex subunit beta-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0006886 [intracellular protein transport] GO:0016192 [vesicle-mediated transport] GO:0030117 [membrane coat] Show all	175 aa 20.2 kDa	No	0
AP4B1-009 ENSP00000358582 ENST00000369569	Q9Y6B7 [Direct mapping] AP-4 complex subunit beta-1 A0A024R0D2 [Target identity:100%; Query identity:100%] AP complex subunit beta Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005802 [trans-Golgi network] GO:0005905 [coated pit] GO:0006886 [intracellular protein transport] GO:0006892 [post-Golgi vesicle-mediated transport] GO:0008565 [protein transporter activity] GO:0015031 [protein transport] GO:0016192 [vesicle-mediated transport] GO:0030117 [membrane coat] GO:0030131 [clathrin adaptor complex] GO:0031904 [endosome lumen] GO:0032588 [trans-Golgi network membrane] GO:0061024 [membrane organization] Show all	739 aa 83.3 kDa	No	0