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CMPK2

CANCER ATLAS

Gene description

 Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041430

GENE INFORMATION

Gene name

 CMPK2 (HGNC Symbol)

Synonyms

 TYKi, UMP-CMPK2

Description

 Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Chromosome

 2

Cytoband

 p25.2

Chromosome location (bp)

 6840570 - 6866635

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134326 (version 83.38)

Entrez gene

 129607

UniProt

 Q5EBM0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5EBM0

Antibodypedia

 CMPK2 antibodies

PROTEIN BROWSER
CMPK2-002
CMPK2-008
CMPK2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CMPK2-002
ENSP00000256722
ENST00000256722
Q5EBM0 [Direct mapping]
UMP-CMP kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004127 [cytidylate kinase activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0004798 [thymidylate kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006227 [dUDP biosynthetic process]
GO:0006233 [dTDP biosynthetic process]
GO:0006235 [dTTP biosynthetic process]
GO:0009041 [uridylate kinase activity]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0033862 [UMP kinase activity]
GO:0071222 [cellular response to lipopolysaccharide]
Show all
 449 aa
49.4 kDa 		No 0
CMPK2-008
ENSP00000384915
ENST00000404168
Q5EBM0 [Direct mapping]
UMP-CMP kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004127 [cytidylate kinase activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0004798 [thymidylate kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006227 [dUDP biosynthetic process]
GO:0006233 [dTDP biosynthetic process]
GO:0006235 [dTTP biosynthetic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0033862 [UMP kinase activity]
Show all
 409 aa
45 kDa 		No 0
CMPK2-201
ENSP00000396385
ENST00000458098
Q5EBM0 [Direct mapping]
UMP-CMP kinase 2, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004127 [cytidylate kinase activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0004798 [thymidylate kinase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0006227 [dUDP biosynthetic process]
GO:0006233 [dTDP biosynthetic process]
GO:0006235 [dTTP biosynthetic process]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0033862 [UMP kinase activity]
Show all
 366 aa
39.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.