Cell atlas - CMPK2 - The Human Protein Atlas

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CMPK2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	CMPK2
Gene description	Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Cell line enhanced (HEL, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, MOLT-4)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA041430
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, MOLT-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041430	SK-MEL-30	Mitochondria

GENE INFORMATION
Gene name	CMPK2 (HGNC Symbol)
Synonyms	TYKi, UMP-CMPK2
Description	Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial (HGNC Symbol)
Entrez gene summary	This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Chromosome	2
Cytoband	p25.2
Chromosome location (bp)	6840570 - 6866635
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134326 (version 83.38)
Entrez gene	129607
UniProt	Q5EBM0 (UniProt - Evidence at protein level)
neXtProt	NX_Q5EBM0
Antibodypedia	CMPK2 antibodies

PROTEIN BROWSER

CMPK2-002	CMPK2-008	CMPK2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CMPK2-002 ENSP00000256722 ENST00000256722	Q5EBM0 [Direct mapping] UMP-CMP kinase 2, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004127 [cytidylate kinase activity] GO:0004550 [nucleoside diphosphate kinase activity] GO:0004798 [thymidylate kinase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006165 [nucleoside diphosphate phosphorylation] GO:0006227 [dUDP biosynthetic process] GO:0006233 [dTDP biosynthetic process] GO:0006235 [dTTP biosynthetic process] GO:0009041 [uridylate kinase activity] GO:0009142 [nucleoside triphosphate biosynthetic process] GO:0033862 [UMP kinase activity] GO:0071222 [cellular response to lipopolysaccharide] Show all	449 aa 49.4 kDa	No	0
CMPK2-008 ENSP00000384915 ENST00000404168	Q5EBM0 [Direct mapping] UMP-CMP kinase 2, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004127 [cytidylate kinase activity] GO:0004550 [nucleoside diphosphate kinase activity] GO:0004798 [thymidylate kinase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006165 [nucleoside diphosphate phosphorylation] GO:0006227 [dUDP biosynthetic process] GO:0006233 [dTDP biosynthetic process] GO:0006235 [dTTP biosynthetic process] GO:0009142 [nucleoside triphosphate biosynthetic process] GO:0033862 [UMP kinase activity] Show all	409 aa 45 kDa	No	0
CMPK2-201 ENSP00000396385 ENST00000458098	Q5EBM0 [Direct mapping] UMP-CMP kinase 2, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004127 [cytidylate kinase activity] GO:0004550 [nucleoside diphosphate kinase activity] GO:0004798 [thymidylate kinase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006165 [nucleoside diphosphate phosphorylation] GO:0006227 [dUDP biosynthetic process] GO:0006233 [dTDP biosynthetic process] GO:0006235 [dTTP biosynthetic process] GO:0009142 [nucleoside triphosphate biosynthetic process] GO:0033862 [UMP kinase activity] Show all	366 aa 39.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.