We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Lymphomas showed moderate to strong cytoplasmic positivity. Cases of breast, ovarian and pancreatic cancers displayed weak nuclear staining. Remaining cancers were in general negative.
GENE INFORMATION
Gene name
DOCK2 (HGNC Symbol)
Synonyms
KIAA0209
Description
Dedicator of cytokinesis 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]
Q92608 [Direct mapping] Dedicator of cytokinesis protein 2
Show all
MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)