We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
A majority of malignant cells displayed moderate cytoplasmic immunoreactivity. Several cases of malignant lymphomas, colorectal and prostate cancers displayed strong staining. Most malignant carcinoids, liver and renal malignancies were negative.
Moderate cytoplasmic positivity was observed in most malignancies. A majority of testicular cancers as well as several colorectal, urothelial and gastric cancers were strongly stained. Renal cancers were in most cases weakly stained or negative.
GENE INFORMATION
Gene name
YARS (HGNC Symbol)
Synonyms
tyrRS, YRS, YTS
Description
Tyrosyl-tRNA synthetase (HGNC Symbol)
Entrez gene summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
