Expression of DSC2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Desmocollin 2

Protein class

Disease related genes, Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Skin cancer

STAINING SUMMARY

HPA011911	HPA012615

GENE INFORMATION
Gene name	DSC2 (HGNC Symbol)
Synonyms	CDHF2, DSC3
Description	Desmocollin 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Chromosome	18
Cytoband	q12.1
Chromosome location (bp)	31058840 - 31102415
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134755 (version 83.38)
Entrez gene	1824
UniProt	Q02487 (UniProt - Evidence at protein level)
neXtProt	NX_Q02487
Antibodypedia	DSC2 antibodies

PROTEIN BROWSER

DSC2-001	DSC2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DSC2-001 ENSP00000280904 ENST00000280904	Q02487 [Direct mapping] Desmocollin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0009267 [cellular response to starvation] GO:0014704 [intercalated disc] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030057 [desmosome] GO:0031410 [cytoplasmic vesicle] GO:0070062 [extracellular exosome] GO:0086042 [cardiac muscle cell-cardiac muscle cell adhesion] GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication] GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0098911 [regulation of ventricular cardiac muscle cell action potential] Show all	901 aa 100 kDa	Yes	1
DSC2-002 ENSP00000251081 ENST00000251081	Q02487 [Direct mapping] Desmocollin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0014704 [intercalated disc] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030057 [desmosome] GO:0031410 [cytoplasmic vesicle] GO:0070062 [extracellular exosome] GO:0086042 [cardiac muscle cell-cardiac muscle cell adhesion] GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication] GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0098911 [regulation of ventricular cardiac muscle cell action potential] Show all	847 aa 93.8 kDa	Yes	1