Expression of DTNA in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Dystrobrevin, alpha

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Glioma

STAINING SUMMARY

CAB015196

GENE INFORMATION
Gene name	DTNA (HGNC Symbol)
Synonyms	D18S892E, DRP3, DTN, DTN-1, DTN-2, DTN-3
Description	Dystrobrevin, alpha (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	q12.1
Chromosome location (bp)	34493290 - 34891844
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134769 (version 83.38)
Entrez gene	1837
UniProt	Q9Y4J8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y4J8
Antibodypedia	DTNA antibodies

PROTEIN BROWSER

DTNA-001	DTNA-002	DTNA-003	DTNA-004	DTNA-005	DTNA-006	DTNA-008	DTNA-009	DTNA-012	DTNA-013	DTNA-016	DTNA-017	DTNA-019	DTNA-020	DTNA-021	DTNA-022	DTNA-023	DTNA-024	DTNA-025	DTNA-026	DTNA-027	DTNA-028	DTNA-029	DTNA-030	DTNA-033	DTNA-034	DTNA-201	DTNA-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DTNA-001 ENSP00000382072 ENST00000399121	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	690 aa 78.1 kDa	No	0
DTNA-002 ENSP00000467720 ENST00000591182	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	391 aa 43.6 kDa	No	0
DTNA-003 ENSP00000336682 ENST00000348997	Q9Y4J8 [Direct mapping] Dystrobrevin alpha A0A024RC32 [Target identity:100%; Query identity:100%] Dystrobrevin Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	567 aa 64.7 kDa	No	0
DTNA-004 ENSP00000322519 ENST00000315456	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	374 aa 42.4 kDa	No	0
DTNA-005 ENSP00000382064 ENST00000399113	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	743 aa 83.9 kDa	No	0
DTNA-006 ENSP00000451516 ENST00000554864	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	371 aa 42 kDa	No	0
DTNA-008 ENSP00000269192 ENST00000269192	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	452 aa 50.4 kDa	No	0
DTNA-009 ENSP00000452255 ENST00000556414	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	395 aa 44.2 kDa	No	0
DTNA-012 ENSP00000468473 ENST00000590598	K7ERZ2 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		133 aa 15.4 kDa	No	0
DTNA-013 ENSP00000465063 ENST00000590412	K7EJ84 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		119 aa 13.9 kDa	No	0
DTNA-016 ENSP00000468138 ENST00000590727	K7ER73 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	104 aa 11.8 kDa	No	0
DTNA-017 ENSP00000468262 ENST00000587723	K7ERH7 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		109 aa 12.4 kDa	No	0
DTNA-019 ENSP00000471143 ENST00000590831	M0R0C4 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		169 aa 18.7 kDa	No	0
DTNA-020 ENSP00000466978 ENST00000588125	K7ENJ7 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		43 aa 5.1 kDa	No	0
DTNA-021 ENSP00000464904 ENST00000588684	K7EIV1 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		18 aa 2.1 kDa	No	0
DTNA-022 ENSP00000466573 ENST00000591816	K7EMN1 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		33 aa 4 kDa	No	0
DTNA-023 ENSP00000468631 ENST00000588949	K7ESB2 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		101 aa 11.6 kDa	No	0
DTNA-024 ENSP00000469121 ENST00000596745	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	320 aa 37 kDa	No	0
DTNA-025 ENSP00000470152 ENST00000598334	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0030165 [PDZ domain binding] GO:0030424 [axon] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0042383 [sarcolemma] GO:0042995 [cell projection] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	724 aa 82.2 kDa	No	1
DTNA-026 ENSP00000473078 ENST00000595022	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	683 aa 77.3 kDa	No	0
DTNA-027 ENSP00000472031 ENST00000598774	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	513 aa 58.9 kDa	No	0
DTNA-028 ENSP00000470716 ENST00000598142	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	686 aa 77.7 kDa	No	0
DTNA-029 ENSP00000473119 ENST00000597599	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	510 aa 58.5 kDa	No	0
DTNA-030 ENSP00000470247 ENST00000601125	M0QZ28 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		365 aa 40.9 kDa	No	0
DTNA-033 ENSP00000471783 ENST00000597674	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	192 aa 22.1 kDa	No	0
DTNA-034 ENSP00000470934 ENST00000599844	M0R021 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		162 aa 18.4 kDa	No	0
DTNA-201 ENSP00000283365 ENST00000283365	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	686 aa 77.7 kDa	No	0
DTNA-202 ENSP00000405819 ENST00000444659	Q9Y4J8 [Direct mapping] Dystrobrevin alpha Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006941 [striated muscle contraction] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007274 [neuromuscular synaptic transmission] GO:0008270 [zinc ion binding] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0045202 [synapse] Show all	743 aa 83.9 kDa	No	0