Fields »
ABOUT
HELP
BLOG
DTNA

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 DTNA

Gene description

 Dystrobrevin, alpha

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 28
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the intermediate filaments, cell junctions & nucleoplasm.

RNA cell category

 Cell line enhanced (SCLC-21H, U-87 MG, NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (uncertain), Cell Junctions (supported), Intermediate filaments (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA071177
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, U-87 MG, NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the intermediate filaments, cell junctions & nucleoplasm.

Main location

 Nucleoplasm (uncertain), Cell Junctions (supported), Intermediate filaments (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA071177 HEK 293 Intermediate filaments
HPA071177 MCF7 Nucleoplasm
Cell Junctions
HPA071177 U-2 OS Intermediate filaments

GENE INFORMATION

Gene name

 DTNA (HGNC Symbol)

Synonyms

 D18S892E, DRP3, DTN, DTN-1, DTN-2, DTN-3

Description

 Dystrobrevin, alpha (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 q12.1

Chromosome location (bp)

 34493290 - 34891844

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134769 (version 83.38)

Entrez gene

 1837

UniProt

 Q9Y4J8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y4J8

Antibodypedia

 DTNA antibodies

PROTEIN BROWSER
«
DTNA-001
DTNA-002
DTNA-003
DTNA-004
DTNA-005
DTNA-006
DTNA-008
DTNA-009
DTNA-012
DTNA-013
DTNA-016
DTNA-017
DTNA-019
DTNA-020
DTNA-021
DTNA-022
DTNA-023
DTNA-024
DTNA-025
DTNA-026
DTNA-027
DTNA-028
DTNA-029
DTNA-030
DTNA-033
DTNA-034
DTNA-201
DTNA-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DTNA-001
ENSP00000382072
ENST00000399121
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 690 aa
78.1 kDa 		No 0
DTNA-002
ENSP00000467720
ENST00000591182
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 391 aa
43.6 kDa 		No 0
DTNA-003
ENSP00000336682
ENST00000348997
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
A0A024RC32 [Target identity:100%; Query identity:100%]
Dystrobrevin
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 567 aa
64.7 kDa 		No 0
DTNA-004
ENSP00000322519
ENST00000315456
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 374 aa
42.4 kDa 		No 0
DTNA-005
ENSP00000382064
ENST00000399113
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 743 aa
83.9 kDa 		No 0
DTNA-006
ENSP00000451516
ENST00000554864
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 371 aa
42 kDa 		No 0
DTNA-008
ENSP00000269192
ENST00000269192
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 452 aa
50.4 kDa 		No 0
DTNA-009
ENSP00000452255
ENST00000556414
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 395 aa
44.2 kDa 		No 0
DTNA-012
ENSP00000468473
ENST00000590598
K7ERZ2 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 133 aa
15.4 kDa 		No 0
DTNA-013
ENSP00000465063
ENST00000590412
K7EJ84 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 119 aa
13.9 kDa 		No 0
DTNA-016
ENSP00000468138
ENST00000590727
K7ER73 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 104 aa
11.8 kDa 		No 0
DTNA-017
ENSP00000468262
ENST00000587723
K7ERH7 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 109 aa
12.4 kDa 		No 0
DTNA-019
ENSP00000471143
ENST00000590831
M0R0C4 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 169 aa
18.7 kDa 		No 0
DTNA-020
ENSP00000466978
ENST00000588125
K7ENJ7 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 43 aa
5.1 kDa 		No 0
DTNA-021
ENSP00000464904
ENST00000588684
K7EIV1 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 18 aa
2.1 kDa 		No 0
DTNA-022
ENSP00000466573
ENST00000591816
K7EMN1 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 33 aa
4 kDa 		No 0
DTNA-023
ENSP00000468631
ENST00000588949
K7ESB2 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 101 aa
11.6 kDa 		No 0
DTNA-024
ENSP00000469121
ENST00000596745
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 320 aa
37 kDa 		No 0
DTNA-025
ENSP00000470152
ENST00000598334
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030424 [axon]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042383 [sarcolemma]
GO:0042995 [cell projection]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 724 aa
82.2 kDa 		No 1
DTNA-026
ENSP00000473078
ENST00000595022
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 683 aa
77.3 kDa 		No 0
DTNA-027
ENSP00000472031
ENST00000598774
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 513 aa
58.9 kDa 		No 0
DTNA-028
ENSP00000470716
ENST00000598142
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 686 aa
77.7 kDa 		No 0
DTNA-029
ENSP00000473119
ENST00000597599
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 510 aa
58.5 kDa 		No 0
DTNA-030
ENSP00000470247
ENST00000601125
M0QZ28 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 365 aa
40.9 kDa 		No 0
DTNA-033
ENSP00000471783
ENST00000597674
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 192 aa
22.1 kDa 		No 0
DTNA-034
ENSP00000470934
ENST00000599844
M0R021 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 162 aa
18.4 kDa 		No 0
DTNA-201
ENSP00000283365
ENST00000283365
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 686 aa
77.7 kDa 		No 0
DTNA-202
ENSP00000405819
ENST00000444659
Q9Y4J8 [Direct mapping]
Dystrobrevin alpha
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006941 [striated muscle contraction]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007274 [neuromuscular synaptic transmission]
GO:0008270 [zinc ion binding]
GO:0030054 [cell junction]
GO:0043234 [protein complex]
GO:0045202 [synapse]
Show all
 743 aa
83.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.