Tissue expression of USP30 - Summary - The Human Protein Atlas

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USP30

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	USP30
Gene description	Ubiquitin specific peptidase 30
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA016952
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	USP30 (HGNC Symbol)
Synonyms	FLJ40511, MGC10702
Description	Ubiquitin specific peptidase 30 (HGNC Symbol)
Entrez gene summary	USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008]
Chromosome	12
Cytoband	q24.11
Chromosome location (bp)	109023089 - 109088026
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135093 (version 83.38)
Entrez gene	84749
UniProt	Q70CQ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q70CQ3
Antibodypedia	USP30 antibodies

PROTEIN BROWSER

USP30-001	USP30-002	USP30-008	USP30-009	USP30-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
USP30-001 ENSP00000257548 ENST00000257548	Q70CQ3 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 30 A0A024RBM3 [Target identity:100%; Query identity:100%] Ubiquitin carboxyl-terminal hydrolase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000422 [mitophagy] GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0008053 [mitochondrial fusion] GO:0016021 [integral component of membrane] GO:0016579 [protein deubiquitination] GO:0035871 [protein K11-linked deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0044313 [protein K6-linked deubiquitination] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	517 aa 58.5 kDa	No	1
USP30-002 ENSP00000376535 ENST00000392784	B3KUS5 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0008234 [cysteine-type peptidase activity] GO:0016021 [integral component of membrane] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	486 aa 55.1 kDa	No	0
USP30-008 ENSP00000438829 ENST00000536393	F5H3L3 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 30 Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0016021 [integral component of membrane] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	146 aa 16.6 kDa	No	0
USP30-009 ENSP00000440837 ENST00000539121	F5GXG2 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 30 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016021 [integral component of membrane] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	95 aa 10.7 kDa	No	1
USP30-010 ENSP00000443678 ENST00000536723	F5H8D3 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 30 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016021 [integral component of membrane] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	177 aa 20.2 kDa	No	1

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