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The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
P16671 [Direct mapping] Platelet glycoprotein 4 A4D1B1 [Target identity:100%; Query identity:100%] CD36 antigen (Collagen type I receptor, thrombospondin receptor); CD36 antigen (Collagen type I receptor, thrombospondin receptor), isoform CRA_a; cDNA, FLJ93369, highly similar to Homo sapiens CD36 antigen (collagen type I receptor, thrombospondinreceptor) (CD36), mRNA
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CD markers Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002221 [pattern recognition receptor signaling pathway] GO:0002224 [toll-like receptor signaling pathway] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002576 [platelet degranulation] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0005041 [low-density lipoprotein receptor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0006898 [receptor-mediated endocytosis] GO:0006910 [phagocytosis, recognition] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007263 [nitric oxide mediated signal transduction] GO:0007596 [blood coagulation] GO:0008035 [high-density lipoprotein particle binding] GO:0008289 [lipid binding] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0010629 [negative regulation of gene expression] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010886 [positive regulation of cholesterol storage] GO:0016020 [membrane] GO:0019915 [lipid storage] GO:0019934 [cGMP-mediated signaling] GO:0030168 [platelet activation] GO:0030169 [low-density lipoprotein particle binding] GO:0030194 [positive regulation of blood coagulation] GO:0030299 [intestinal cholesterol absorption] GO:0030301 [cholesterol transport] GO:0030666 [endocytic vesicle membrane] GO:0031092 [platelet alpha granule membrane] GO:0031526 [brush border membrane] GO:0032735 [positive regulation of interleukin-12 production] GO:0032755 [positive regulation of interleukin-6 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0033993 [response to lipid] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034197 [triglyceride transport] GO:0034381 [plasma lipoprotein particle clearance] GO:0034383 [low-density lipoprotein particle clearance] GO:0035634 [response to stilbenoid] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042953 [lipoprotein transport] GO:0042992 [negative regulation of transcription factor import into nucleus] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043277 [apoptotic cell clearance] GO:0043410 [positive regulation of MAPK cascade] GO:0044130 [negative regulation of growth of symbiont in host] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0044539 [long-chain fatty acid import] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045177 [apical part of cell] GO:0045335 [phagocytic vesicle] GO:0050431 [transforming growth factor beta binding] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050830 [defense response to Gram-positive bacterium] GO:0050892 [intestinal absorption] GO:0050909 [sensory perception of taste] GO:0055096 [low-density lipoprotein particle mediated signaling] GO:0060100 [positive regulation of phagocytosis, engulfment] GO:0060907 [positive regulation of macrophage cytokine production] GO:0070053 [thrombospondin receptor activity] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070508 [cholesterol import] GO:0070542 [response to fatty acid] GO:0070543 [response to linoleic acid] GO:0070892 [lipoteichoic acid receptor activity] GO:0071221 [cellular response to bacterial lipopeptide] GO:0071222 [cellular response to lipopolysaccharide] GO:0071223 [cellular response to lipoteichoic acid] GO:0071447 [cellular response to hydroperoxide] GO:0071813 [lipoprotein particle binding] GO:2000121 [regulation of removal of superoxide radicals] GO:2000334 [positive regulation of blood microparticle formation] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2000505 [regulation of energy homeostasis]
P16671 [Direct mapping] Platelet glycoprotein 4 A4D1B1 [Target identity:100%; Query identity:100%] CD36 antigen (Collagen type I receptor, thrombospondin receptor); CD36 antigen (Collagen type I receptor, thrombospondin receptor), isoform CRA_a; cDNA, FLJ93369, highly similar to Homo sapiens CD36 antigen (collagen type I receptor, thrombospondinreceptor) (CD36), mRNA
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CD markers Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002224 [toll-like receptor signaling pathway] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002576 [platelet degranulation] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0005041 [low-density lipoprotein receptor activity] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0006898 [receptor-mediated endocytosis] GO:0007155 [cell adhesion] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007263 [nitric oxide mediated signal transduction] GO:0007596 [blood coagulation] GO:0008289 [lipid binding] GO:0009986 [cell surface] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0016020 [membrane] GO:0019915 [lipid storage] GO:0019934 [cGMP-mediated signaling] GO:0030168 [platelet activation] GO:0030169 [low-density lipoprotein particle binding] GO:0030299 [intestinal cholesterol absorption] GO:0030301 [cholesterol transport] GO:0030666 [endocytic vesicle membrane] GO:0031092 [platelet alpha granule membrane] GO:0031526 [brush border membrane] GO:0033993 [response to lipid] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034197 [triglyceride transport] GO:0034381 [plasma lipoprotein particle clearance] GO:0034383 [low-density lipoprotein particle clearance] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042953 [lipoprotein transport] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0044539 [long-chain fatty acid import] GO:0045087 [innate immune response] GO:0045335 [phagocytic vesicle] GO:0050431 [transforming growth factor beta binding] GO:0050892 [intestinal absorption] GO:0050909 [sensory perception of taste] GO:0070053 [thrombospondin receptor activity] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070508 [cholesterol import] GO:0070542 [response to fatty acid] GO:0070543 [response to linoleic acid] GO:0071813 [lipoprotein particle binding] GO:2000505 [regulation of energy homeostasis]
P16671 [Direct mapping] Platelet glycoprotein 4 A4D1B1 [Target identity:100%; Query identity:100%] CD36 antigen (Collagen type I receptor, thrombospondin receptor); CD36 antigen (Collagen type I receptor, thrombospondin receptor), isoform CRA_a; cDNA, FLJ93369, highly similar to Homo sapiens CD36 antigen (collagen type I receptor, thrombospondinreceptor) (CD36), mRNA
Show all
CD markers Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002224 [toll-like receptor signaling pathway] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002576 [platelet degranulation] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0005041 [low-density lipoprotein receptor activity] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0006898 [receptor-mediated endocytosis] GO:0007155 [cell adhesion] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007263 [nitric oxide mediated signal transduction] GO:0007596 [blood coagulation] GO:0008289 [lipid binding] GO:0009986 [cell surface] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0016020 [membrane] GO:0019915 [lipid storage] GO:0019934 [cGMP-mediated signaling] GO:0030168 [platelet activation] GO:0030169 [low-density lipoprotein particle binding] GO:0030299 [intestinal cholesterol absorption] GO:0030301 [cholesterol transport] GO:0030666 [endocytic vesicle membrane] GO:0031092 [platelet alpha granule membrane] GO:0031526 [brush border membrane] GO:0033993 [response to lipid] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034197 [triglyceride transport] GO:0034381 [plasma lipoprotein particle clearance] GO:0034383 [low-density lipoprotein particle clearance] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042953 [lipoprotein transport] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0044539 [long-chain fatty acid import] GO:0045087 [innate immune response] GO:0045335 [phagocytic vesicle] GO:0050431 [transforming growth factor beta binding] GO:0050892 [intestinal absorption] GO:0050909 [sensory perception of taste] GO:0070053 [thrombospondin receptor activity] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070508 [cholesterol import] GO:0070542 [response to fatty acid] GO:0070543 [response to linoleic acid] GO:0071813 [lipoprotein particle binding] GO:2000505 [regulation of energy homeostasis]
P16671 [Direct mapping] Platelet glycoprotein 4 A4D1B1 [Target identity:100%; Query identity:100%] CD36 antigen (Collagen type I receptor, thrombospondin receptor); CD36 antigen (Collagen type I receptor, thrombospondin receptor), isoform CRA_a; cDNA, FLJ93369, highly similar to Homo sapiens CD36 antigen (collagen type I receptor, thrombospondinreceptor) (CD36), mRNA
Show all
CD markers Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002224 [toll-like receptor signaling pathway] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002576 [platelet degranulation] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0005041 [low-density lipoprotein receptor activity] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0006898 [receptor-mediated endocytosis] GO:0007155 [cell adhesion] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007263 [nitric oxide mediated signal transduction] GO:0007596 [blood coagulation] GO:0008289 [lipid binding] GO:0009986 [cell surface] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0016020 [membrane] GO:0019915 [lipid storage] GO:0019934 [cGMP-mediated signaling] GO:0030168 [platelet activation] GO:0030169 [low-density lipoprotein particle binding] GO:0030299 [intestinal cholesterol absorption] GO:0030301 [cholesterol transport] GO:0030666 [endocytic vesicle membrane] GO:0031092 [platelet alpha granule membrane] GO:0031526 [brush border membrane] GO:0033993 [response to lipid] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034197 [triglyceride transport] GO:0034381 [plasma lipoprotein particle clearance] GO:0034383 [low-density lipoprotein particle clearance] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042953 [lipoprotein transport] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0044539 [long-chain fatty acid import] GO:0045087 [innate immune response] GO:0045335 [phagocytic vesicle] GO:0050431 [transforming growth factor beta binding] GO:0050892 [intestinal absorption] GO:0050909 [sensory perception of taste] GO:0070053 [thrombospondin receptor activity] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070508 [cholesterol import] GO:0070542 [response to fatty acid] GO:0070543 [response to linoleic acid] GO:0071813 [lipoprotein particle binding] GO:2000505 [regulation of energy homeostasis]
P16671 [Direct mapping] Platelet glycoprotein 4 A4D1B1 [Target identity:100%; Query identity:100%] CD36 antigen (Collagen type I receptor, thrombospondin receptor); CD36 antigen (Collagen type I receptor, thrombospondin receptor), isoform CRA_a; cDNA, FLJ93369, highly similar to Homo sapiens CD36 antigen (collagen type I receptor, thrombospondinreceptor) (CD36), mRNA
Show all
CD markers Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002224 [toll-like receptor signaling pathway] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002576 [platelet degranulation] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0005041 [low-density lipoprotein receptor activity] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0006898 [receptor-mediated endocytosis] GO:0007155 [cell adhesion] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007263 [nitric oxide mediated signal transduction] GO:0007596 [blood coagulation] GO:0008289 [lipid binding] GO:0009986 [cell surface] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0016020 [membrane] GO:0019915 [lipid storage] GO:0019934 [cGMP-mediated signaling] GO:0030168 [platelet activation] GO:0030169 [low-density lipoprotein particle binding] GO:0030299 [intestinal cholesterol absorption] GO:0030301 [cholesterol transport] GO:0030666 [endocytic vesicle membrane] GO:0031092 [platelet alpha granule membrane] GO:0031526 [brush border membrane] GO:0033993 [response to lipid] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034197 [triglyceride transport] GO:0034381 [plasma lipoprotein particle clearance] GO:0034383 [low-density lipoprotein particle clearance] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042953 [lipoprotein transport] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0044539 [long-chain fatty acid import] GO:0045087 [innate immune response] GO:0045335 [phagocytic vesicle] GO:0050431 [transforming growth factor beta binding] GO:0050892 [intestinal absorption] GO:0050909 [sensory perception of taste] GO:0070053 [thrombospondin receptor activity] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070508 [cholesterol import] GO:0070542 [response to fatty acid] GO:0070543 [response to linoleic acid] GO:0071813 [lipoprotein particle binding] GO:2000505 [regulation of energy homeostasis]