Cell atlas - TES - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TES
Gene description	Testin LIM domain protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & focal adhesion sites. In addition localized to the plasma membrane & cell junctions.
RNA cell category	Cell line enhanced (EFO-21)
Protein evidence	Evidence at protein level
Main location	Localized to the Focal adhesion sites (validated), Cytosol (validated)
Additional location	In addition localized to the Plasma membrane (approved), Cell Junctions (approved)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA015269 , HPA018123
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & focal adhesion sites. In addition localized to the plasma membrane & cell junctions.

Main location

Focal adhesion sites (validated), Cytosol (validated)

Additional location

Plasma membrane (approved), Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA015269	A-431	Cell Junctions
HPA015269	A-431	Cytosol
HPA015269	SiHa	Focal adhesion sites
HPA015269	SiHa	Cytosol
HPA018123	A-431	Plasma membrane
HPA018123	A-431	Cytosol
HPA018123	SiHa	Plasma membrane
		Focal adhesion sites
		Cytosol

GENE INFORMATION
Gene name	TES (HGNC Symbol)
Synonyms	DKFZP586B2022, TESS-2, TESTIN
Description	Testin LIM domain protein (HGNC Symbol)
Entrez gene summary	Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]
Chromosome	7
Cytoband	q31.2
Chromosome location (bp)	116210493 - 116258783
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135269 (version 83.38)
Entrez gene	26136
UniProt	Q9UGI8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UGI8
Antibodypedia	TES antibodies

PROTEIN BROWSER

TES-001	TES-002	TES-005	TES-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TES-001 ENSP00000350937 ENST00000358204	Q9UGI8 [Direct mapping] Testin A4D0U5 [Target identity:100%; Query identity:100%] Testis derived transcript (3 LIM domains); Testis derived transcript (3 LIM domains), isoform CRA_d Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0044822 [poly(A) RNA binding] Show all	421 aa 48 kDa	No	0
TES-002 ENSP00000377121 ENST00000393481	Q9UGI8 [Direct mapping] Testin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0030054 [cell junction] GO:0043234 [protein complex] GO:0044822 [poly(A) RNA binding] Show all	412 aa 46.9 kDa	No	0
TES-005 ENSP00000377124 ENST00000393484	H7BYK1 [Direct mapping] Testin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] GO:0042127 [regulation of cell proliferation] Show all	192 aa 21.9 kDa	No	0
TES-008 ENSP00000413002 ENST00000455989	F8W7T0 [Direct mapping] Testin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	79 aa 9 kDa	No	0