Expression of NT5E in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

5'-nucleotidase, ecto (CD73)

Protein class

CD markers, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA017357

GENE INFORMATION
Gene name	NT5E (HGNC Symbol)
Synonyms	CALJA, CD73, eN, eNT, NT5
Description	5'-nucleotidase, ecto (CD73) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Chromosome	6
Cytoband	q14.3
Chromosome location (bp)	85449584 - 85495791
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135318 (version 83.38)
Entrez gene	4907
UniProt	P21589 (UniProt - Evidence at protein level)
neXtProt	NX_P21589
Antibodypedia	NT5E antibodies

PROTEIN BROWSER

NT5E-001	NT5E-002	NT5E-003	NT5E-004	NT5E-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NT5E-001 ENSP00000257770 ENST00000257770	P21589 [Direct mapping] 5'-nucleotidase Show all	Enzymes ENZYME proteins Hydrolases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006144 [purine nucleobase metabolic process] GO:0006164 [purine nucleotide biosynthetic process] GO:0006195 [purine nucleotide catabolic process] GO:0006196 [AMP catabolic process] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006259 [DNA metabolic process] GO:0007159 [leukocyte cell-cell adhesion] GO:0007420 [brain development] GO:0008198 [ferrous iron binding] GO:0008253 [5'-nucleotidase activity] GO:0009166 [nucleotide catabolic process] GO:0009986 [cell surface] GO:0010044 [response to aluminum ion] GO:0016020 [membrane] GO:0016311 [dephosphorylation] GO:0016787 [hydrolase activity] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0031225 [anchored component of membrane] GO:0044281 [small molecule metabolic process] GO:0046085 [adenosine metabolic process] GO:0046086 [adenosine biosynthetic process] GO:0046135 [pyrimidine nucleoside catabolic process] GO:0046872 [metal ion binding] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0050728 [negative regulation of inflammatory response] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] GO:0097060 [synaptic membrane] Show all	574 aa 63.4 kDa	Yes	1
NT5E-002 ENSP00000358660 ENST00000369646	Q96B60 [Direct mapping] 5'-nucleotidase; 5'-nucleotidase, ecto (CD73), isoform CRA_c; NT5E protein Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0009166 [nucleotide catabolic process] GO:0016787 [hydrolase activity] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0046872 [metal ion binding] Show all	264 aa 28.8 kDa	Yes	0
NT5E-003 ENSP00000414674 ENST00000416334	H0Y7R7 [Direct mapping] 5'-nucleotidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0009166 [nucleotide catabolic process] GO:0016787 [hydrolase activity] Show all	230 aa 25.6 kDa	No	0
NT5E-004 ENSP00000387630 ENST00000437581	H0Y3X5 [Direct mapping] 5'-nucleotidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0009166 [nucleotide catabolic process] GO:0016787 [hydrolase activity] Show all	179 aa 20.2 kDa	No	0
NT5E-201 ENSP00000358665 ENST00000369651	P21589 [Direct mapping] 5'-nucleotidase Show all	Enzymes ENZYME proteins Hydrolases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006144 [purine nucleobase metabolic process] GO:0006195 [purine nucleotide catabolic process] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006259 [DNA metabolic process] GO:0007159 [leukocyte cell-cell adhesion] GO:0008253 [5'-nucleotidase activity] GO:0009166 [nucleotide catabolic process] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0031225 [anchored component of membrane] GO:0044281 [small molecule metabolic process] GO:0046135 [pyrimidine nucleoside catabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	524 aa 57.9 kDa	Yes	1