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NT5E

GENERAL INFORMATION

Gene name

 NT5E

Gene description

 5'-nucleotidase, ecto (CD73)

Protein class

 CD markers
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cervix, uterine)
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA017357
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Cervix, uterine

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cervix, uterine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 NT5E (HGNC Symbol)

Synonyms

 CALJA, CD73, eN, eNT, NT5

Description

 5'-nucleotidase, ecto (CD73) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Chromosome

 6

Cytoband

 q14.3

Chromosome location (bp)

 85449584 - 85495791

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135318 (version 83.38)

Entrez gene

 4907

UniProt

 P21589 (UniProt - Evidence at protein level)

neXtProt

 NX_P21589

Antibodypedia

 NT5E antibodies

PROTEIN BROWSER
NT5E-001
NT5E-002
NT5E-003
NT5E-004
NT5E-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NT5E-001
ENSP00000257770
ENST00000257770
P21589 [Direct mapping]
5'-nucleotidase
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Enzymes
   ENZYME proteins
   Hydrolases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006195 [purine nucleotide catabolic process]
GO:0006196 [AMP catabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006259 [DNA metabolic process]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0007420 [brain development]
GO:0008198 [ferrous iron binding]
GO:0008253 [5'-nucleotidase activity]
GO:0009166 [nucleotide catabolic process]
GO:0009986 [cell surface]
GO:0010044 [response to aluminum ion]
GO:0016020 [membrane]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0031225 [anchored component of membrane]
GO:0044281 [small molecule metabolic process]
GO:0046085 [adenosine metabolic process]
GO:0046086 [adenosine biosynthetic process]
GO:0046135 [pyrimidine nucleoside catabolic process]
GO:0046872 [metal ion binding]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0050728 [negative regulation of inflammatory response]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0097060 [synaptic membrane]
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 574 aa
63.4 kDa 		Yes 1
NT5E-002
ENSP00000358660
ENST00000369646
Q96B60 [Direct mapping]
5'-nucleotidase; 5'-nucleotidase, ecto (CD73), isoform CRA_c; NT5E protein
Show all
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0009166 [nucleotide catabolic process]
GO:0016787 [hydrolase activity]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0046872 [metal ion binding]
Show all
 264 aa
28.8 kDa 		Yes 0
NT5E-003
ENSP00000414674
ENST00000416334
H0Y7R7 [Direct mapping]
5'-nucleotidase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0009166 [nucleotide catabolic process]
GO:0016787 [hydrolase activity]
Show all
 230 aa
25.6 kDa 		No 0
NT5E-004
ENSP00000387630
ENST00000437581
H0Y3X5 [Direct mapping]
5'-nucleotidase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0009166 [nucleotide catabolic process]
GO:0016787 [hydrolase activity]
Show all
 179 aa
20.2 kDa 		No 0
NT5E-201
ENSP00000358665
ENST00000369651
P21589 [Direct mapping]
5'-nucleotidase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006144 [purine nucleobase metabolic process]
GO:0006195 [purine nucleotide catabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006259 [DNA metabolic process]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0008253 [5'-nucleotidase activity]
GO:0009166 [nucleotide catabolic process]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0031225 [anchored component of membrane]
GO:0044281 [small molecule metabolic process]
GO:0046135 [pyrimidine nucleoside catabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 524 aa
57.9 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.