Tissue expression of B4GALNT1 - Summary - The Human Protein Atlas

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B4GALNT1

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	B4GALNT1
Gene description	Beta-1,4-N-acetyl-galactosaminyl transferase 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (cerebellum, cerebral cortex, caudate, hippocampus, hypothalamus)
FANTOM5:	Group enriched (cerebellum, caudate, hippocampus, brain)

Protein evidence

Evidence at protein level

Protein expression

Selective expression of cells in the CNS and peripheral nerves.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA008968 , HPA015128
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebellum, cerebral cortex, caudate, hippocampus, hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebellum, caudate, hippocampus, brain)

GENE INFORMATION
Gene name	B4GALNT1 (HGNC Symbol)
Synonyms	beta1-4GalNAc-T, GALGT, SPG26
Description	Beta-1,4-N-acetyl-galactosaminyl transferase 1 (HGNC Symbol)
Entrez gene summary	GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Chromosome	12
Cytoband	q13.3
Chromosome location (bp)	57623410 - 57633355
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135454 (version 83.38)
Entrez gene	2583
UniProt	Q00973 (UniProt - Evidence at protein level)
neXtProt	NX_Q00973
Antibodypedia	B4GALNT1 antibodies

PROTEIN BROWSER

B4GALNT1-002	B4GALNT1-003	B4GALNT1-004	B4GALNT1-005	B4GALNT1-006	B4GALNT1-010	B4GALNT1-014	B4GALNT1-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
B4GALNT1-002 ENSP00000341562 ENST00000341156	Q00973 [Direct mapping] Beta-1,4 N-acetylgalactosaminyltransferase 1 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001574 [ganglioside biosynthetic process] GO:0003947 [(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0006687 [glycosphingolipid metabolic process] GO:0007283 [spermatogenesis] GO:0008376 [acetylgalactosaminyltransferase activity] GO:0016020 [membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0019915 [lipid storage] GO:0030173 [integral component of Golgi membrane] GO:0030259 [lipid glycosylation] Show all	533 aa 58.9 kDa	Yes	0
B4GALNT1-003 ENSP00000473533 ENST00000449184	B4DSP5 [Direct mapping] Beta-1,4 N-acetylgalactosaminyltransferase 1; cDNA FLJ60142, highly similar to Beta-1,4 N-acetylgalactosaminyltransferase 1 (EC 2.4.1.92) Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016740 [transferase activity] Show all	304 aa 33.1 kDa	Yes	0
B4GALNT1-004 ENSP00000450303 ENST00000550764	Q00973 [Direct mapping] Beta-1,4 N-acetylgalactosaminyltransferase 1 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003947 [(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0006687 [glycosphingolipid metabolic process] GO:0016020 [membrane] GO:0030173 [integral component of Golgi membrane] GO:0030259 [lipid glycosylation] Show all	328 aa 35.5 kDa	Yes	0
B4GALNT1-005 ENSP00000448500 ENST00000552350	Q00973 [Direct mapping] Beta-1,4 N-acetylgalactosaminyltransferase 1 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003947 [(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0006687 [glycosphingolipid metabolic process] GO:0016020 [membrane] GO:0030173 [integral component of Golgi membrane] GO:0030259 [lipid glycosylation] Show all	328 aa 35.5 kDa	Yes	0
B4GALNT1-006 ENSP00000401601 ENST00000418555	Q00973 [Direct mapping] Beta-1,4 N-acetylgalactosaminyltransferase 1 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003947 [(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0006687 [glycosphingolipid metabolic process] GO:0016020 [membrane] GO:0030173 [integral component of Golgi membrane] GO:0030259 [lipid glycosylation] Show all	478 aa 52.9 kDa	Yes	0
B4GALNT1-010 ENSP00000446566 ENST00000551220	F8VR44 [Direct mapping] Beta-1,4 N-acetylgalactosaminyltransferase 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		120 aa 13.1 kDa	Yes	0
B4GALNT1-014 ENSP00000447945 ENST00000548888	F8VU35 [Direct mapping] Beta-1,4 N-acetylgalactosaminyltransferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		237 aa 25.5 kDa	Yes	0
B4GALNT1-016 ENSP00000448577 ENST00000547741	H0YI57 [Direct mapping] Beta-1,4 N-acetylgalactosaminyltransferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		151 aa 16.7 kDa	No	0

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The Human Protein Atlas

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