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HNRNPA1

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GENERAL INFORMATION

Gene name

 HNRNPA1

Gene description

 Heterogeneous nuclear ribonucleoprotein A1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA005812 , HPA007185
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA005812 A549 Nucleoplasm
HPA005812 PC-3 Nucleoplasm
HPA005812 U-2 OS Nucleoplasm
HPA007185 RH-30 Nucleoplasm
HPA007185 SH-SY5Y Nucleoplasm
HPA007185 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 HNRNPA1 (HGNC Symbol)

Synonyms

 ALS20, hnRNP-A1, hnRNPA1, HNRPA1

Description

 Heterogeneous nuclear ribonucleoprotein A1 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 54280193 - 54287088

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135486 (version 83.38)

Entrez gene

 3178

UniProt

 P09651 (UniProt - Evidence at protein level)

neXtProt

 NX_P09651

Antibodypedia

 HNRNPA1 antibodies

PROTEIN BROWSER
HNRNPA1-001
HNRNPA1-002
HNRNPA1-012
HNRNPA1-013
HNRNPA1-014
HNRNPA1-015
HNRNPA1-018
HNRNPA1-019
HNRNPA1-023

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HNRNPA1-001
ENSP00000448617
ENST00000546500
P09651 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein A1 Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
A0A024RB53 [Target identity:100%; Query identity:100%]
Heterogeneous nuclear ribonucleoprotein A1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0006405 [RNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030529 [ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051028 [mRNA transport]
GO:0051168 [nuclear export]
GO:0051170 [nuclear import]
GO:0070062 [extracellular exosome]
GO:0071013 [catalytic step 2 spliceosome]
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 320 aa
34.2 kDa 		No 0
HNRNPA1-002
ENSP00000341826
ENST00000340913
P09651 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein A1 Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
A0A024RAZ7 [Target identity:100%; Query identity:100%]
Heterogeneous nuclear ribonucleoprotein A1, isoform CRA_b
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000380 [alternative mRNA splicing, via spliceosome]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0006405 [RNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030529 [ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051028 [mRNA transport]
GO:0051168 [nuclear export]
GO:0051170 [nuclear import]
GO:0070062 [extracellular exosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 372 aa
38.7 kDa 		No 0
HNRNPA1-012
ENSP00000447260
ENST00000547276
P09651 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein A1 Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0006405 [RNA export from nucleus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030529 [ribonucleoprotein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051028 [mRNA transport]
GO:0051168 [nuclear export]
GO:0051170 [nuclear import]
GO:0070062 [extracellular exosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 267 aa
29.4 kDa 		No 0
HNRNPA1-013
ENSP00000447782
ENST00000548688
F8VZ49 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein A1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 231 aa
25.7 kDa 		No 0
HNRNPA1-014
ENSP00000448917
ENST00000550994
F8VYN5 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein A1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 113 aa
12.9 kDa 		No 0
HNRNPA1-015
ENSP00000448229
ENST00000547708
F8W646 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein A1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 156 aa
16.8 kDa 		No 0
HNRNPA1-018
ENSP00000446486
ENST00000550482
H0YH80 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein A1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 191 aa
19.5 kDa 		No 0
HNRNPA1-019
ENSP00000448117
ENST00000551702
F8VTQ5 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein A1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
Show all
 145 aa
16.5 kDa 		No 0
HNRNPA1-023
ENSP00000333504
ENST00000330752
F8W6I7 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein A1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 307 aa
33.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.