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A majority of malignant cells displayed moderate to strong nuclear immunoreactivity. Most cases of prostate, testicular and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
HEY2 (HGNC Symbol)
Synonyms
bHLHb32, HERP1, HESR2
Description
Hes-related family bHLH transcription factor with YRPW motif 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]