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Gene name

Class

Subclass

Chromosome

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In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

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Score

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Antibodies

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HEY2
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

HEY2

Gene description

Hes-related family bHLH transcription factor with YRPW motif 2

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

Evidence at protein level

Protein expression

General nuclear expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA030205
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

HEY2 (HGNC Symbol)

Synonyms

bHLHb32, HERP1, HESR2

Description

Hes-related family bHLH transcription factor with YRPW motif 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

q22.31

Chromosome location (bp)

125747664 - 125761269

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135547 (version 83.38)

Entrez gene

23493

UniProt

Q9UBP5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UBP5

Antibodypedia

HEY2 antibodies

PROTEIN BROWSER

HEY2-001
HEY2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HEY2-001
ENSP00000357348
ENST00000368364
Q9UBP5 [Direct mapping]
Hairy/enhancer-of-split related with YRPW motif protein 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific]
GO:0000988 [transcription factor activity, protein binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001568 [blood vessel development]
GO:0001570 [vasculogenesis]
GO:0003150 [muscular septum morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003171 [atrioventricular valve development]
GO:0003184 [pulmonary valve morphogenesis]
GO:0003186 [tricuspid valve morphogenesis]
GO:0003195 [tricuspid valve formation]
GO:0003199 [endocardial cushion to mesenchymal transition involved in heart valve formation]
GO:0003208 [cardiac ventricle morphogenesis]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003215 [cardiac right ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003300 [cardiac muscle hypertrophy]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007219 [Notch signaling pathway]
GO:0007389 [pattern specification process]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0009948 [anterior/posterior axis specification]
GO:0010460 [positive regulation of heart rate]
GO:0010468 [regulation of gene expression]
GO:0010621 [negative regulation of transcription by transcription factor localization]
GO:0010629 [negative regulation of gene expression]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0014031 [mesenchymal cell development]
GO:0014898 [cardiac muscle hypertrophy in response to stress]
GO:0016580 [Sin3 complex]
GO:0017053 [transcriptional repressor complex]
GO:0035910 [ascending aorta morphogenesis]
GO:0035912 [dorsal aorta morphogenesis]
GO:0035939 [microsatellite binding]
GO:0036304 [umbilical cord morphogenesis]
GO:0042826 [histone deacetylase binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045165 [cell fate commitment]
GO:0045607 [regulation of auditory receptor cell differentiation]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0051145 [smooth muscle cell differentiation]
GO:0055015 [ventricular cardiac muscle cell development]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060317 [cardiac epithelial to mesenchymal transition]
GO:0060347 [heart trabecula formation]
GO:0060411 [cardiac septum morphogenesis]
GO:0060412 [ventricular septum morphogenesis]
GO:0060413 [atrial septum morphogenesis]
GO:0060633 [negative regulation of transcription initiation from RNA polymerase II promoter]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0060840 [artery development]
GO:0060842 [arterial endothelial cell differentiation]
GO:0060948 [cardiac vascular smooth muscle cell development]
GO:0060977 [coronary vasculature morphogenesis]
GO:0061156 [pulmonary artery morphogenesis]
GO:0061314 [Notch signaling involved in heart development]
GO:0065004 [protein-DNA complex assembly]
GO:0090102 [cochlea development]
GO:0097084 [vascular smooth muscle cell development]
GO:2000678 [negative regulation of transcription regulatory region DNA binding]
GO:2000723 [negative regulation of cardiac vascular smooth muscle cell differentiation]
GO:2000820 [negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation]
GO:2001212 [regulation of vasculogenesis]
Show all
337 aa
35.8 kDa
No 0
HEY2-002
ENSP00000357349
ENST00000368365
Q5TF93 [Direct mapping]
Hairy/enhancer-of-split-related with YRPW motif protein 2
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
291 aa
30.8 kDa
No 0

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