Several cases of endometrial cancers showed moderate to strong membranous staining. Rare cases of adenocarcinoma of lung displayed moderate to strong cytoplasmic and membranous positivity. Remaining cancer tissues were weakly stained or negative.
Carboxypeptidase M (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]