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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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CPM
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CPM

Gene description

Carboxypeptidase M

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (adipose tissue)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Membranous expression in endometrial glands and fallopian tube.

DATA RELIABILITY

Data reliability
description

Presumed off target binding observed and disregarded. Caution, Splice and/or transcript discrepancy exists. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA002657
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CPM

Synonyms

Description

Carboxypeptidase M (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q15

Chromosome location (bp)

68842197 - 68971570

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135678 (version 83.38)

Entrez gene

1368

UniProt

P14384 (UniProt - Evidence at protein level)

neXtProt

NX_P14384

Antibodypedia

CPM antibodies

PROTEIN BROWSER

CPM-001
CPM-002
CPM-005
CPM-007
CPM-009
CPM-011
CPM-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CPM-001
ENSP00000448517
ENST00000551568
P14384 [Direct mapping]
Carboxypeptidase M
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0004181 [metallocarboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0009653 [anatomical structure morphogenesis]
GO:0009986 [cell surface]
GO:0031225 [anchored component of membrane]
GO:0070062 [extracellular exosome]
Show all
443 aa
50.5 kDa
Yes 1
CPM-002
ENSP00000447255
ENST00000546373
P14384 [Direct mapping]
Carboxypeptidase M
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0004181 [metallocarboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0009653 [anatomical structure morphogenesis]
GO:0009986 [cell surface]
GO:0031225 [anchored component of membrane]
GO:0070062 [extracellular exosome]
Show all
443 aa
50.5 kDa
Yes 1
CPM-005
ENSP00000446799
ENST00000548954
F8W111 [Direct mapping]
Carboxypeptidase M
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004181 [metallocarboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
249 aa
28.3 kDa
Yes 0
CPM-007
ENSP00000449911
ENST00000548262
F8VVI6 [Direct mapping]
Carboxypeptidase M
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004181 [metallocarboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
136 aa
15.4 kDa
Yes 0
CPM-009
ENSP00000448078
ENST00000549781
F8VU13 [Direct mapping]
Carboxypeptidase M
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004181 [metallocarboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
72 aa
8.1 kDa
Yes 0
CPM-011
ENSP00000447455
ENST00000551897
H0YHN7 [Direct mapping]
Carboxypeptidase M
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004181 [metallocarboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
198 aa
22.6 kDa
No 0
CPM-201
ENSP00000339157
ENST00000338356
P14384 [Direct mapping]
Carboxypeptidase M
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004180 [carboxypeptidase activity]
GO:0004181 [metallocarboxypeptidase activity]
GO:0004185 [serine-type carboxypeptidase activity]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0009653 [anatomical structure morphogenesis]
GO:0009986 [cell surface]
GO:0031225 [anchored component of membrane]
GO:0070062 [extracellular exosome]
Show all
443 aa
50.5 kDa
Yes 1

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