Expression of CHST5 in cancer - Summary

CANCER ATLAS

Gene description

Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5

Protein class

Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043804

GENE INFORMATION
Gene name	CHST5 (HGNC Symbol)
Synonyms	FLJ22167, I-GLCNAC-6-ST
Description	Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon and small intestine. [provided by RefSeq, Aug 2011]
Chromosome	16
Cytoband	q23.1
Chromosome location (bp)	75528535 - 75535247
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135702 (version 83.38)
Entrez gene	23563
UniProt	Q9GZS9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9GZS9
Antibodypedia	CHST5 antibodies

PROTEIN BROWSER

CHST5-001	CHST5-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHST5-001 ENSP00000338783 ENST00000336257	Q9GZS9 [Direct mapping] Carbohydrate sulfotransferase 5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001517 [N-acetylglucosamine 6-O-sulfotransferase activity] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006477 [protein sulfation] GO:0006790 [sulfur compound metabolic process] GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0018146 [keratan sulfate biosynthetic process] GO:0030203 [glycosaminoglycan metabolic process] GO:0031228 [intrinsic component of Golgi membrane] GO:0042339 [keratan sulfate metabolic process] GO:0044281 [small molecule metabolic process] Show all	411 aa 46.2 kDa	Yes	0
CHST5-002 ENSP00000454375 ENST00000565039	H3BMG8 [Direct mapping] Carbohydrate sulfotransferase 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all		99 aa 11.1 kDa	No	1