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CHST5

GENERAL INFORMATION

Gene name

 CHST5

Gene description

 Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5

Protein class

 Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (duodenum, small intestine, rectum, colon)
GTEx:Group enriched (small intestine, colon)
FANTOM5:Group enriched (small intestine, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA043804
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, small intestine, rectum, colon)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, colon)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, colon)

GENE INFORMATION

Gene name

 CHST5 (HGNC Symbol)

Synonyms

 FLJ22167, I-GLCNAC-6-ST

Description

 Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon and small intestine. [provided by RefSeq, Aug 2011]

Chromosome

 16

Cytoband

 q23.1

Chromosome location (bp)

 75528535 - 75535247

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135702 (version 83.38)

Entrez gene

 23563

UniProt

 Q9GZS9 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9GZS9

Antibodypedia

 CHST5 antibodies

PROTEIN BROWSER
CHST5-001
CHST5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHST5-001
ENSP00000338783
ENST00000336257
Q9GZS9 [Direct mapping]
Carbohydrate sulfotransferase 5
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001517 [N-acetylglucosamine 6-O-sulfotransferase activity]
GO:0005794 [Golgi apparatus]
GO:0005975 [carbohydrate metabolic process]
GO:0006044 [N-acetylglucosamine metabolic process]
GO:0006477 [protein sulfation]
GO:0006790 [sulfur compound metabolic process]
GO:0008146 [sulfotransferase activity]
GO:0016021 [integral component of membrane]
GO:0018146 [keratan sulfate biosynthetic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0031228 [intrinsic component of Golgi membrane]
GO:0042339 [keratan sulfate metabolic process]
GO:0044281 [small molecule metabolic process]
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 411 aa
46.2 kDa 		Yes 0
CHST5-002
ENSP00000454375
ENST00000565039
H3BMG8 [Direct mapping]
Carbohydrate sulfotransferase 5
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
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 99 aa
11.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.