Cell atlas - VPS36 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	VPS36
Gene description	Vacuolar protein sorting 36 homolog (S. cerevisiae)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles & lysosome. In addition localized to the plasma membrane & cell junctions.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported), Lysosomes (supported)
Additional location	In addition localized to the Plasma membrane (supported), Cell Junctions (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA039734
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles & lysosome. In addition localized to the plasma membrane & cell junctions.

Main location

Vesicles (supported), Lysosomes (supported)

Additional location

Plasma membrane (supported), Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA039734	A-431	Vesicles
		Plasma membrane
		Cell Junctions
HPA039734	U-2 OS	Vesicles
HPA039734	U-2 OS	Lysosomes
HPA039734	U-251 MG	Vesicles

GENE INFORMATION
Gene name	VPS36 (HGNC Symbol)
Synonyms	C13orf9, CGI-145, Eap45
Description	Vacuolar protein sorting 36 homolog (S. cerevisiae) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]
Chromosome	13
Cytoband	q14.3
Chromosome location (bp)	52412602 - 52450628
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136100 (version 83.38)
Entrez gene	51028
UniProt	Q86VN1 (UniProt - Evidence at protein level)
neXtProt	NX_Q86VN1
Antibodypedia	VPS36 antibodies

PROTEIN BROWSER

VPS36-001	VPS36-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VPS36-001 ENSP00000367299 ENST00000378060	Q86VN1 [Direct mapping] Vacuolar protein-sorting-associated protein 36 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000814 [ESCRT II complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005764 [lysosome] GO:0005768 [endosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008022 [protein C-terminus binding] GO:0016197 [endosomal transport] GO:0031902 [late endosome membrane] GO:0032266 [phosphatidylinositol-3-phosphate binding] GO:0043130 [ubiquitin binding] GO:0043328 [protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	386 aa 43.8 kDa	No	0
VPS36-201 ENSP00000484968 ENST00000611132	Q86VN1 [Direct mapping] Vacuolar protein-sorting-associated protein 36 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000814 [ESCRT II complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008022 [protein C-terminus binding] GO:0016197 [endosomal transport] GO:0031902 [late endosome membrane] GO:0032266 [phosphatidylinositol-3-phosphate binding] GO:0043130 [ubiquitin binding] GO:0043328 [protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	328 aa 37 kDa	No	0