Expression of RNASEH2B in cancer - Summary

CANCER ATLAS

Gene description

Ribonuclease H2, subunit B

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA040084

GENE INFORMATION
Gene name	RNASEH2B (HGNC Symbol)
Synonyms	AGS2, DLEU8, FLJ11712
Description	Ribonuclease H2, subunit B (HGNC Symbol)
Entrez gene summary	RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
Chromosome	13
Cytoband	q14.3
Chromosome location (bp)	50909678 - 50973745
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136104 (version 83.38)
Entrez gene	79621
UniProt	Q5TBB1 (UniProt - Evidence at protein level)
neXtProt	NX_Q5TBB1
Antibodypedia	RNASEH2B antibodies

PROTEIN BROWSER

RNASEH2B-001	RNASEH2B-008	RNASEH2B-009	RNASEH2B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNASEH2B-001 ENSP00000337623 ENST00000336617	Q5TBB1 [Direct mapping] Ribonuclease H2 subunit B Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0004523 [RNA-DNA hybrid ribonuclease activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006401 [RNA catabolic process] GO:0009259 [ribonucleotide metabolic process] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0010629 [negative regulation of gene expression] GO:0032299 [ribonuclease H2 complex] GO:0048146 [positive regulation of fibroblast proliferation] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] GO:2000001 [regulation of DNA damage checkpoint] Show all	312 aa 35.1 kDa	No	0
RNASEH2B-008 ENSP00000482701 ENST00000616907	A0A087WZJ6 [Direct mapping] Ribonuclease H2 subunit B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	84 aa 9.3 kDa	No	0
RNASEH2B-009 ENSP00000389877 ENST00000422660	Q5TBB1 [Direct mapping] Ribonuclease H2 subunit B Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006401 [RNA catabolic process] GO:0032299 [ribonuclease H2 complex] Show all	257 aa 29 kDa	No	0
RNASEH2B-201 ENSP00000481236 ENST00000611510	A0A087WXR7 [Direct mapping] Ribonuclease H2 subunit B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	332 aa 37.5 kDa	No	0