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CKAP2

GENERAL INFORMATION

Gene name

 CKAP2

Gene description

 Cytoskeleton associated protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissues, highest expression in testis.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA008410 , HPA027821
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Breast
N/A
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CKAP2 (HGNC Symbol)

Synonyms

 FLJ10749, LB1, se20-10, TMAP

Description

 Cytoskeleton associated protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]

Chromosome

 13

Cytoband

 q14.3

Chromosome location (bp)

 52455429 - 52476628

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136108 (version 83.38)

Entrez gene

 26586

UniProt

 Q8WWK9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WWK9

Antibodypedia

 CKAP2 antibodies

PROTEIN BROWSER
CKAP2-001
CKAP2-002
CKAP2-003
CKAP2-004
CKAP2-005
CKAP2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CKAP2-001
ENSP00000258607
ENST00000258607
Q8WWK9 [Direct mapping]
Cytoskeleton-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0000922 [spindle pole]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005881 [cytoplasmic microtubule]
GO:0006915 [apoptotic process]
GO:0015630 [microtubule cytoskeleton]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 682 aa
76.9 kDa 		No 0
CKAP2-002
ENSP00000367273
ENST00000378034
Q8WWK9 [Direct mapping]
Cytoskeleton-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0000922 [spindle pole]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005881 [cytoplasmic microtubule]
GO:0006915 [apoptotic process]
GO:0015630 [microtubule cytoskeleton]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 494 aa
55.3 kDa 		No 0
CKAP2-003
ENSP00000367276
ENST00000378037
Q8WWK9 [Direct mapping]
Cytoskeleton-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0000922 [spindle pole]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005881 [cytoplasmic microtubule]
GO:0006915 [apoptotic process]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0015630 [microtubule cytoskeleton]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 683 aa
77 kDa 		No 0
CKAP2-004
ENSP00000417830
ENST00000490903
Q8WWK9 [Direct mapping]
Cytoskeleton-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0000922 [spindle pole]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005881 [cytoplasmic microtubule]
GO:0006915 [apoptotic process]
GO:0015630 [microtubule cytoskeleton]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 634 aa
71.2 kDa 		No 0
CKAP2-005
ENSP00000418224
ENST00000480747
C9J7Y4 [Direct mapping]
Cytoskeleton-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 97 aa
10.9 kDa 		No 0
CKAP2-006
ENSP00000418431
ENST00000468284
C9J649 [Direct mapping]
Cytoskeleton-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 94 aa
10.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.