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Cases of squamous cell carcinomas, malignant gliomas, endometrial, ovarian, urothelial and pancreatic cancers displayed moderate cytoplasmic and/or membranous immunoreactivity. Remaining cancers were in general negative.
Several cases of thyroid, skin, lung and urothelial cancers showed moderate to strong cytoplasmic and membranous staining. Few cases of pancreas and endometrial cancers exhibited moderate membranous positivity. Remaining malignant cells were generally negative.
GENE INFORMATION
Gene name
SCEL (HGNC Symbol)
Synonyms
FLJ21667, MGC22531
Description
Sciellin (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
