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SCEL

GENERAL INFORMATION

Gene name

 SCEL

Gene description

 Sciellin

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (esophagus, skin)
GTEx:Tissue enhanced (esophagus, skin)
FANTOM5:Tissue enhanced (esophagus, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Selective membranous and cytoplasmic expression in squamous epithelia and pneumocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA039737 , HPA040154
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, tonsil)

GENE INFORMATION

Gene name

 SCEL (HGNC Symbol)

Synonyms

 FLJ21667, MGC22531

Description

 Sciellin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q22.3

Chromosome location (bp)

 77535674 - 77645263

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136155 (version 83.38)

Entrez gene

 8796

UniProt

 O95171 (UniProt - Evidence at protein level)

neXtProt

 NX_O95171

Antibodypedia

 SCEL antibodies

PROTEIN BROWSER
SCEL-001
SCEL-002
SCEL-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCEL-001
ENSP00000366454
ENST00000377246
O95171 [Direct mapping]
Sciellin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001533 [cornified envelope]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0008544 [epidermis development]
GO:0009790 [embryo development]
GO:0030216 [keratinocyte differentiation]
GO:0070062 [extracellular exosome]
Show all
 668 aa
75.3 kDa 		No 0
SCEL-002
ENSP00000302579
ENST00000349847
O95171 [Direct mapping]
Sciellin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001533 [cornified envelope]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0008544 [epidermis development]
GO:0009790 [embryo development]
GO:0030216 [keratinocyte differentiation]
GO:0070062 [extracellular exosome]
Show all
 688 aa
77.6 kDa 		No 0
SCEL-201
ENSP00000437895
ENST00000535157
O95171 [Direct mapping]
Sciellin
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001533 [cornified envelope]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0008544 [epidermis development]
GO:0009790 [embryo development]
GO:0030216 [keratinocyte differentiation]
GO:0070062 [extracellular exosome]
Show all
 646 aa
72.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.